DNA–protein crosslink proteases in genome stability

Annamaria Ruggiano; Kristijan Ramadan

doi:10.1038/s42003-020-01539-3

Communications Biology (Jan 2021)

DNA–protein crosslink proteases in genome stability

Annamaria Ruggiano,
Kristijan Ramadan

Affiliations

Annamaria Ruggiano: Medical Research Council (MRC) Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford
Kristijan Ramadan: Medical Research Council (MRC) Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford

DOI: https://doi.org/10.1038/s42003-020-01539-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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DNA–protein crosslink (DPC) proteases digest the protein component of crosslinks that otherwise can cause genomic instability and disease. Ruggiano and Ramadan discuss recent insights into the roles of DPC proteases in the repair of DPCs and beyond.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal