A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis

Tsveta S. Malinova; Ana Angulo-Urarte; Julian Nüchel; Marina Tauber; Miesje M. van der Stoel; Vera Janssen; Annett de Haan; Anouk G. Groenen; Merel Tebbens; Mariona Graupera; Markus Plomann; Stephan Huveneers

doi:10.1038/s41467-021-22873-y

Nature Communications (May 2021)

A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis

Tsveta S. Malinova,
Ana Angulo-Urarte,
Julian Nüchel,
Marina Tauber,
Miesje M. van der Stoel,
Vera Janssen,
Annett de Haan,
Anouk G. Groenen,
Merel Tebbens,
Mariona Graupera,
Markus Plomann,
Stephan Huveneers

Affiliations

Tsveta S. Malinova: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Ana Angulo-Urarte: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Julian Nüchel: Center for Biochemistry, Faculty of Medicine, University of Cologne
Marina Tauber: Center for Biochemistry, Faculty of Medicine, University of Cologne
Miesje M. van der Stoel: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Vera Janssen: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Annett de Haan: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Anouk G. Groenen: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Merel Tebbens: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC
Mariona Graupera: Vascular Biology and Signaling Group, ProCURE, Oncobell Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), Gran Via de l’Hospitalet 199, 08908 L’Hospitalet de Llobregat
Markus Plomann: Center for Biochemistry, Faculty of Medicine, University of Cologne
Stephan Huveneers: Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, location AMC

DOI: https://doi.org/10.1038/s41467-021-22873-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 18

Abstract

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Communication between endothelial leader and follower cells during collective cell migration is crucial for vascular development. Here, the authors show that PACSIN2 guides collective cell migration and angiogenesis by recruiting a protein trafficking complex to asymmetric cell-cell junctions, controlling local junction plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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