Nature Communications (Jan 2018)
GWAS of epigenetic aging rates in blood reveals a critical role for TERT
- Ake T. Lu,
- Luting Xue,
- Elias L. Salfati,
- Brian H. Chen,
- Luigi Ferrucci,
- Daniel Levy,
- Roby Joehanes,
- Joanne M. Murabito,
- Douglas P. Kiel,
- Pei-Chien Tsai,
- Idil Yet,
- Jordana T. Bell,
- Massimo Mangino,
- Toshiko Tanaka,
- Allan F. McRae,
- Riccardo E. Marioni,
- Peter M. Visscher,
- Naomi R. Wray,
- Ian J. Deary,
- Morgan E. Levine,
- Austin Quach,
- Themistocles Assimes,
- Philip S. Tsao,
- Devin Absher,
- James D. Stewart,
- Yun Li,
- Alex P. Reiner,
- Lifang Hou,
- Andrea A. Baccarelli,
- Eric A. Whitsel,
- Abraham Aviv,
- Alexia Cardona,
- Felix R. Day,
- Nicholas J. Wareham,
- John R. B. Perry,
- Ken K. Ong,
- Kenneth Raj,
- Kathryn L. Lunetta,
- Steve Horvath
Affiliations
- Ake T. Lu
- Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- Luting Xue
- Department of Biostatistics, Boston University School of Public Health
- Elias L. Salfati
- Department of Medicine, Stanford University School of Medicine
- Brian H. Chen
- Intramural Research Program, National Institute on Aging, National Institutes of Health
- Luigi Ferrucci
- Intramural Research Program, National Institute on Aging, National Institutes of Health
- Daniel Levy
- National Heart, Lung and Blood Institute
- Roby Joehanes
- National Heart, Lung and Blood Institute
- Joanne M. Murabito
- Department of Medicine, Section of General Medicine, Boston University School of Medicine
- Douglas P. Kiel
- Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Centre, Harvard Medical School
- Pei-Chien Tsai
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Idil Yet
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Jordana T. Bell
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Massimo Mangino
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Toshiko Tanaka
- Intramural Research Program, National Institute on Aging, National Institutes of Health
- Allan F. McRae
- Institute for Molecular Bioscience, The University of Queensland
- Riccardo E. Marioni
- Institute for Molecular Bioscience, The University of Queensland
- Peter M. Visscher
- Institute for Molecular Bioscience, The University of Queensland
- Naomi R. Wray
- Institute for Molecular Bioscience, The University of Queensland
- Ian J. Deary
- Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh
- Morgan E. Levine
- Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- Austin Quach
- Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- Themistocles Assimes
- Department of Medicine, Stanford University School of Medicine
- Philip S. Tsao
- Department of Medicine, Stanford University School of Medicine
- Devin Absher
- HudsonAlpha Institute for Biotechnology
- James D. Stewart
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Yun Li
- Department of Genetics, School of Medicine, University of North Carolina
- Alex P. Reiner
- Fred Hutchinson Cancer Research Center Box 358080, WHI Clinical Coordinating Ctr/Public Health Sciences M3-A4
- Lifang Hou
- Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Chicago
- Andrea A. Baccarelli
- Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health
- Eric A. Whitsel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Abraham Aviv
- The Center for Human Development and Aging, University of Medicine and Dentistry, New Jersey Medical School
- Alexia Cardona
- Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- Felix R. Day
- Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- Nicholas J. Wareham
- Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- John R. B. Perry
- Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- Ken K. Ong
- Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus
- Kenneth Raj
- Radiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton
- Kathryn L. Lunetta
- Department of Biostatistics, Boston University School of Public Health
- Steve Horvath
- Human Genetics, David Geffen School of Medicine, University of California, Los Angeles
- DOI
- https://doi.org/10.1038/s41467-017-02697-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres.
