Nature Communications (Oct 2018)
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
- Chao Sheng,
- Johannes Jungverdorben,
- Hendrik Wiethoff,
- Qiong Lin,
- Lea J. Flitsch,
- Daniela Eckert,
- Matthias Hebisch,
- Julia Fischer,
- Jaideep Kesavan,
- Beatrice Weykopf,
- Linda Schneider,
- Dominik Holtkamp,
- Heinz Beck,
- Andreas Till,
- Ullrich Wüllner,
- Michael J. Ziller,
- Wolfgang Wagner,
- Michael Peitz,
- Oliver Brüstle
Affiliations
- Chao Sheng
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Johannes Jungverdorben
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Hendrik Wiethoff
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Qiong Lin
- Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School
- Lea J. Flitsch
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Daniela Eckert
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Matthias Hebisch
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Julia Fischer
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Jaideep Kesavan
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Beatrice Weykopf
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Linda Schneider
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Dominik Holtkamp
- Institute of Experimental Epileptology and Cognition Research, Life & Brain Center, University of Bonn Medical Center
- Heinz Beck
- Institute of Experimental Epileptology and Cognition Research, Life & Brain Center, University of Bonn Medical Center
- Andreas Till
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Ullrich Wüllner
- German Center for Neurodegenerative Diseases (DZNE)
- Michael J. Ziller
- Max Planck Institute of Psychiatry
- Wolfgang Wagner
- Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Medical School
- Michael Peitz
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- Oliver Brüstle
- Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-06398-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.
