Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

Fucheng Luo; Amanda Phuong Tran; Li Xin; Chandrika Sanapala; Bradley T. Lang; Jerry Silver; Yan Yang

doi:10.1038/s41467-018-06505-6

Nature Communications (Oct 2018)

Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis

Fucheng Luo,
Amanda Phuong Tran,
Li Xin,
Chandrika Sanapala,
Bradley T. Lang,
Jerry Silver,
Yan Yang

Affiliations

Fucheng Luo: Department of Neurology, Case Western Reserve University School of Medicine
Amanda Phuong Tran: Department of Neurosciences, Case Western Reserve University School of Medicine
Li Xin: Department of Neurology, Case Western Reserve University School of Medicine
Chandrika Sanapala: Department of Neurosciences, Case Western Reserve University School of Medicine
Bradley T. Lang: BioEnterprise
Jerry Silver: Department of Neurosciences, Case Western Reserve University School of Medicine
Yan Yang: Department of Neurology, Case Western Reserve University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-06505-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Demyelination failure in multiple sclerosis (MS) may contribute to the disease progression. This study shows that chondroitin sulfate proteoglycans (CSPGs) can inhibit remyelination in an animal model of MS via CSPG binding with the receptor PTPσ on oligodendrocyte progenitor cells, and disruption of this interaction can promote recovery in the animal models of MS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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