Journal of Orthopaedic Surgery and Research (Jan 2022)

Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

  • Yang Yang,
  • Shudian Lin,
  • Zhou Yang,
  • Yanyan Huang,
  • Feng Zhan

DOI
https://doi.org/10.1186/s13018-022-02939-3
Journal volume & issue
Vol. 17, no. 1
pp. 1 – 12

Abstract

Read online

Highlights 1. Circ_0001947 is abnormally upregulated in RA synovial tissues and RA-FLSs. 2. Circ_0001947 silencing inhibits cell proliferation, invasion, migration and inflammatory response and induces apoptosis in RA-FLSs. 3. Circ_0001947 sponges miR-671-5p, which directly interacts with STAT3. 4. Circ_0001947 regulates RA-FLS progression via miR-671-5p/STAT3 axis.

Keywords