Nature Communications (Jun 2021)

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

  • Volker Boehm,
  • Sabrina Kueckelmann,
  • Jennifer V. Gerbracht,
  • Sebastian Kallabis,
  • Thiago Britto-Borges,
  • Janine Altmüller,
  • Marcus Krüger,
  • Christoph Dieterich,
  • Niels H. Gehring

DOI
https://doi.org/10.1038/s41467-021-24046-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.