Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase

Rizaldy C. Zapata; Maria Carretero; Felipe Castellani Gomes Reis; Besma S. Chaudry; Jachelle Ofrecio; Dinghong Zhang; Roman Sasik; Theodore Ciaraldi; Michael Petrascheck; Olivia Osborn

doi:10.1038/s41467-022-32764-5

Nature Communications (Aug 2022)

Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase

Rizaldy C. Zapata,
Maria Carretero,
Felipe Castellani Gomes Reis,
Besma S. Chaudry,
Jachelle Ofrecio,
Dinghong Zhang,
Roman Sasik,
Theodore Ciaraldi,
Michael Petrascheck,
Olivia Osborn

Affiliations

Rizaldy C. Zapata: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Maria Carretero: Department of Molecular Medicine and Department of Neuroscience, The Scripps Research Institute
Felipe Castellani Gomes Reis: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Besma S. Chaudry: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Jachelle Ofrecio: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Dinghong Zhang: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Roman Sasik: Center for Computational Biology & Bioinformatics, School of Medicine, University of California San Diego
Theodore Ciaraldi: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego
Michael Petrascheck: Department of Molecular Medicine and Department of Neuroscience, The Scripps Research Institute
Olivia Osborn: Division of Endocrinology and Metabolism, School of Medicine, University of California San Diego

DOI: https://doi.org/10.1038/s41467-022-32764-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Energy metabolism is dysregulated in obesity, and some if these changes persist after weight loss and may contribute to weight regain. Here the authors report that a vacuolar-type H+ ATPase, ATP6v0a1, is induced in adipocytes during obesity and persists after weight loss, and regulates food intake and weight gain in C. elegans and mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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