Nature Communications (Feb 2016)

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

  • Justin A. Boddey,
  • Matthew T. O’Neill,
  • Sash Lopaticki,
  • Teresa G. Carvalho,
  • Anthony N. Hodder,
  • Thomas Nebl,
  • Stephan Wawra,
  • Pieter van West,
  • Zeinab Ebrahimzadeh,
  • Dave Richard,
  • Sven Flemming,
  • Tobias Spielmann,
  • Jude Przyborski,
  • Jeff J. Babon,
  • Alan F. Cowman

DOI
https://doi.org/10.1038/ncomms10470
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via cleavage by plasmepsin V.