Bezmiâlem Science (Jan 2017)

Relationship of Bradykinin B2 Receptor Gene C-58T Variation with Total-Cholesterol and Glucose in Essential Hypertension

  • Belgin SÜSLEYİCİ,
  • Meliha KOLDEMİR GÜNDÜZ,
  • Seniyye Ülgen ZENGİN,
  • Penbe ÇAĞATAY,
  • Hasan Mert BOZKUŞ,
  • Nur BAKIR,
  • Mustafa TAŞKIN

DOI
https://doi.org/10.14235/bs.2016.738
Journal volume & issue
Vol. 5, no. 1
pp. 7 – 15

Abstract

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Objective:Hypertension, which affects 25% of the world’s population, is a complex disease, with 30% genes affecting its pathogenesis. In this study, we aimed to examine the frequency of the bradykinin B2 receptor gene C-58T genotypes in patients with essential hypertension and non-hypertensive controls. In addition, we evaluated the effects of C-58T genotypes on demographic characteristics, phenotypes related to obesity, and hypertension.Methods:Genotyping was performed in 63 hypertensive patients and 56 non-hypertensive subjects by PCR-RFLP.Results:The frequency of bradykinin B2 receptor gene C-58T genotypes in hypertensive patients and control subjects was 25.4% and 28.6% for homozygous wild-type (T/T), 49.2% and 58.9% for heterozygous (T/C), and 25.4% and 12.5% for homozygous polymorphic (C/C) genotypes, respectively. Genotype frequencies did not differ significantly among study groups. The C allele was found to have an increasing effect on blood glucose levels (p=0.05) and decreasing effect on total cholesterol levels (p=0.008) in hypertensive patients, whereas it was found to have an increasing effect on waist circumference (p=0.041) in control subjects. Hypertensive patients with C allele were found to use sulfonylurea drugs (p=0.021) at a higher frequency than those with T allele. Further, hypertensive patients with T allele were found to use diuretic drugs (p=0.007) at a higher frequency than those with C allele.Conclusions:The C-58T polymorphism is found to have a positive association with total cholesterol levels, blood glucose levels, and waist circumference but no association with systolic/diastolic blood pressure.

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