Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese Children and Adolescents

Abstract

Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for protection against LDL oxidation, was less investigated in obese children and adolescents. Therefore, we aimed to measure lactonase, paraoxonase and arylesterase activities, oxidized LDL (ox-LDL) and malondialdehyde (MDA) levels in obese children and adolescents.

Keywords

• paraoxonase
• lactonase
• arylesterase
• childhood obesity
• low density lipoproteins
• malondialdehyde
• paraoxonaza
• lactonaza
• arilesteraza
• obezitate infantila
• lipoproteine cu densitate joasa
• malondialdehida