Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis

Do Hoon Kwon; Feng Zhang; Justin G. Fedor; Yang Suo; Seok-Yong Lee

doi:10.1038/s41467-022-30602-2

Nature Communications (May 2022)

Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis

Do Hoon Kwon,
Feng Zhang,
Justin G. Fedor,
Yang Suo,
Seok-Yong Lee

Affiliations

Do Hoon Kwon: Department of Biochemistry, Duke University School of Medicine
Feng Zhang: Department of Biochemistry, Duke University School of Medicine
Justin G. Fedor: Department of Biochemistry, Duke University School of Medicine
Yang Suo: Department of Biochemistry, Duke University School of Medicine
Seok-Yong Lee: Department of Biochemistry, Duke University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-30602-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Cryo-EM often yields multiple protein conformations within a single dataset. Using the thermal titration methods and cryo-EM, Do Hoon Kwon et al. elucidate the conformational trajectory of the TRPV1 with resiniferatoxin (RTx) bound.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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