Acylated Aminooligosaccharides with Inhibitory Effects against α-Amylase from <em>Streptomyces</em> sp. HO1518

Abstract

Five new acylated aminooligosaccharides (1–5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.

Keywords

• <em>Streptomyces </em>sp. HO1518
• acylated aminooligosaccharides
• porcine pancreatic α-amylase (PPA) inhibitor