Nature Communications (Jun 2017)
Inherited determinants of early recurrent somatic mutations in prostate cancer
- Alessandro Romanel,
- Sonia Garritano,
- Blerta Stringa,
- Mirjam Blattner,
- Davide Dalfovo,
- Dimple Chakravarty,
- David Soong,
- Kellie A. Cotter,
- Gianluca Petris,
- Priyanka Dhingra,
- Paola Gasperini,
- Anna Cereseto,
- Olivier Elemento,
- Andrea Sboner,
- Ekta Khurana,
- Alberto Inga,
- Mark A. Rubin,
- Francesca Demichelis
Affiliations
- Alessandro Romanel
- Centre for Integrative Biology, University of Trento
- Sonia Garritano
- Centre for Integrative Biology, University of Trento
- Blerta Stringa
- Centre for Integrative Biology, University of Trento
- Mirjam Blattner
- Centre for Integrative Biology, University of Trento
- Davide Dalfovo
- Centre for Integrative Biology, University of Trento
- Dimple Chakravarty
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- David Soong
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Kellie A. Cotter
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- Gianluca Petris
- Centre for Integrative Biology, University of Trento
- Priyanka Dhingra
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Paola Gasperini
- Centre for Integrative Biology, University of Trento
- Anna Cereseto
- Centre for Integrative Biology, University of Trento
- Olivier Elemento
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- Andrea Sboner
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- Ekta Khurana
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- Alberto Inga
- Centre for Integrative Biology, University of Trento
- Mark A. Rubin
- Caryl and Israel Englander Institute for Precision Medicine, New York Presbyterian Hospital–Weill Cornell Medicine
- Francesca Demichelis
- Centre for Integrative Biology, University of Trento
- DOI
- https://doi.org/10.1038/s41467-017-00046-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Prostate cancer is a heterogeneous disease, and many cases show somatic mutations of SPOP. Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass through a hormone dependent DNA damage response.
