Nature Communications (Nov 2019)
Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases
- Pablo D. Cárdenas,
- Prashant D. Sonawane,
- Uwe Heinig,
- Adam Jozwiak,
- Sayantan Panda,
- Bekele Abebie,
- Yana Kazachkova,
- Margarita Pliner,
- Tamar Unger,
- Dalia Wolf,
- Itai Ofner,
- Ester Vilaprinyo,
- Sagit Meir,
- Olga Davydov,
- Amit Gal-on,
- Saul Burdman,
- Ashok Giri,
- Dani Zamir,
- Tali Scherf,
- Jedrzej Szymanski,
- Ilana Rogachev,
- Asaph Aharoni
Affiliations
- Pablo D. Cárdenas
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Prashant D. Sonawane
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Uwe Heinig
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Adam Jozwiak
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Sayantan Panda
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Bekele Abebie
- Department of Plant Pathology and Weed Research, Agricultural Research Organization, Volcani Center
- Yana Kazachkova
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Margarita Pliner
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Tamar Unger
- Israel Structural Proteomics Centre, Weizmann Institute of Science
- Dalia Wolf
- Department of Vegetable Research, Agricultural Research Organization, Volcani Center
- Itai Ofner
- The Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
- Ester Vilaprinyo
- Department of Basic Medical Sciences, University of Lleida-IRBLleida
- Sagit Meir
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Olga Davydov
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Amit Gal-on
- Department of Plant Pathology and Weed Research, Agricultural Research Organization, Volcani Center
- Saul Burdman
- Department of Plant Pathology and Microbiology and The Otto Warburg Minerva Center for Agricultural Biotechnology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
- Ashok Giri
- Plant Molecular Biology Unit, Division of Biochemical Sciences, Council of Scientific and Industrial Research-National Chemical Laboratory
- Dani Zamir
- The Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem
- Tali Scherf
- NMR unit, Department of Chemical Research Support, Weizmann Institute of Science
- Jedrzej Szymanski
- Department of Molecular Genetics, Leibniz Institute of Plant Genetics and Crop Plant Research, OT Gatersleben
- Ilana Rogachev
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- Asaph Aharoni
- Department of Plant and Environmental Sciences, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-019-13211-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Steroidal glycoalkaloids (SGAs) accumulate in Solanum, but their hydroxylating enzymes are unknown. Here, the authors report 2-OXOGLUTARATE DEPENDENT DIOXYGENASE enzymes that catalyze the committed hydroxylation steps in the biosynthesis of leptinine insecticidal compounds in wild potato or non-bitter SGAs in cultivated tomato.
