Molecules (Jun 2014)

An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation

  • Dajana Gašo-Sokač,
  • Valentina Bušić,
  • Mario Cetina,
  • Marijana Jukić

DOI
https://doi.org/10.3390/molecules19067610
Journal volume & issue
Vol. 19, no. 6
pp. 7610 – 7620

Abstract

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Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%–94%) were obtained in acetone in very short reaction times (3–5 min) as well as in the solvent-free procedure (42%–78%) in very short reaction times (7–10 min) too. Effective metodologies for the preparation of pyridoxal oxime quaternary salts, having the advantagies of being eco-friendly, easy to handle, and performed in shorter reactions time are presented. The structure of compound 7, in which a 4-fluorophenacyl moiety is bonded to the pyridinium ring nitrogen atom, was unequivocally confirmed by the single-crystal X-ray diffraction method.

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