Медицинская иммунология (Jul 2014)
PATIENT-CENTRED SCREENING FOR PRIMARY IMMUNODEFICIENCY, A MULTI-STAGE DIAGNOSTIC PROTOCOL DESIGNED FOR NONIMMUNOLOGISTS: 2011 UPDATE
- E. de Vries,
- A. A. Cardona,
- A. H. Abdul Latiff,
- R. Badolato,
- N. Brodszki,
- A. J. Cant,
- J. Carbone,
- J. T. Casper,
- A. Ciznar,
- A. V. Cochino,
- B. Derfalvi,
- G. J. Driessen,
- R. Elfeky,
- D. El-Ghoneimy,
- T. Espanol,
- A. Etzioni,
- E. Gambineri,
- K. Gilmour,
- L. I. Gonzalez-Granado,
- M. N. Guseva,
- M. H. Haverkamp,
- M. Helminen,
- M. Honig,
- M. G. Kanariou,
- M. Kirschfink,
- C. Klein,
- T. W. Kuijpers,
- N. Kutukculer,
- B. Martire,
- I. Meyts,
- T. Niehues,
- C. Pignata,
- S. M. Reda,
- E. D. Renner,
- N. Rezaei,
- M. Rizzi,
- M. A. Sampalo Lainz,
- R. B. Sargur,
- A. Sediva,
- M. G. Seidel,
- S. L. Seneviratne,
- P. Soler-Palacin,
- A. Tommasini,
- K. Warnatz
Affiliations
- E. de Vries
- Jeroen Bosch Hospital ’s-Hertogenbosch
- A. A. Cardona
- Instituto Nacional de Pediatr a, Universidad Aut noma de M xico, Ciudad de Mexico
- A. H. Abdul Latiff
- Division of Clinical Immunology and Paediatrics School of Medicine and Health Sciences, Monash University, Sunway Campus
- R. Badolato
- Clinica Pediatrica dell’Universit di Brescia c/o Spedali Civili, Brescia, Italy
- N. Brodszki
- Lund University Hospital, Lund
- A. J. Cant
- Great North Children’s Hospital, Newcastle upon Tyne
- J. Carbone
- Department of Immunology, Gregorio Mara on Hospital, Madrid
- J. T. Casper
- Medical College of Wisconsin, MACC Fund Research Center, Milwaukee
- A. Ciznar
- Comenius University Medical School, Children’ University Hospital, Bratislava
- A. V. Cochino
- University of Medicine and Pharmacy ‘Carol Davila’, Bucharest
- B. Derfalvi
- Semmelweis University Budapest, Budapest
- G. J. Driessen
- Erasmus MC, University Medical Center Rotterdam, Rotterdam
- R. Elfeky
- Ain Shams University, Cairo
- D. El-Ghoneimy
- Ain Shams University, Cairo
- T. Espanol
- University Hospital Vall d’Hebron, Barcelona
- A. Etzioni
- Meyer’s Children Hospital, Faculty of Medicine, Technion, Haifa
- E. Gambineri
- University of Florence, ‘Anna Meyer’ Children’s Hospital, Florence
- K. Gilmour
- Great Ormond Street for Children NHS Trust, London
- L. I. Gonzalez-Granado
- Hospital 12 octubre, Madrid
- M. N. Guseva
- St. Petersburg Pediatric Medical Academy, St. Petersburg
- M. H. Haverkamp
- Leiden University Medical Center, Leiden
- M. Helminen
- University Hospital of Tampere, Tampere
- M. Honig
- University Hospital Ulm, Ulm
- M. G. Kanariou
- Specific Center & Referral Center for Primary Immunodeficiencies – Paediatric Immunology, ‘Aghia Sophia’ Children’s Hospital, Athens
- M. Kirschfink
- Institute of Immunology, University of Heidelberg, Heidelberg
- C. Klein
- University Children’s Hospital, Dr von Haunersches Kinderspital, Munich
- T. W. Kuijpers
- Emma Children’s Hospital, Academic Medical Center, Amsterdam
- N. Kutukculer
- Ege University, Izmir
- B. Martire
- Policlinico Universit di Bari, Bari
- I. Meyts
- University Hospitals Leuven, Leuven
- T. Niehues
- Helios Klinikum Krefeld; Krefeld Immunodeficiency Centre KIDZ, Krefeld
- C. Pignata
- ‘Federico II’ University, Naples
- S. M. Reda
- Ain Shams University, Cairo
- E. D. Renner
- University Children’s Hospital, Ludwig Maximilians Universit t, Munchen
- N. Rezaei
- Children’s Medical Center, Tehran University of Medical Sciences, Tehran
- M. Rizzi
- University Medical Center Freiburg, Freiburg
- M. A. Sampalo Lainz
- Puerta del Mar Universitary Hospital, Cadiz
- R. B. Sargur
- Northern General Hospital, Sheffield
- A. Sediva
- Institute of Immunology, University Hospital Motol, Prague
- M. G. Seidel
- St Anna Children’s Hospital, Vienna
- S. L. Seneviratne
- St Mary’s Hospital and Imperial College, London
- P. Soler-Palacin
- Vall d’Hebron University Hospital, Barcelona
- A. Tommasini
- Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste
- K. Warnatz
- University Hospital of Freiburg, Freiburg
- DOI
- https://doi.org/10.15789/1563-0625-2013-5-477-492
- Journal volume & issue
-
Vol. 15,
no. 5
pp. 477 – 492
Abstract
Abstract. Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated themulti-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage.
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