STUDY OF CHANGES IN THE RELATIONSHIP OF SOME BIOCHEMICAL PARAMETERS OF BLOOD SERUM IN METABOLIC SYNDROME IN AZERBAIJAN

Abstract

The aim. To study changes in the indices of carbohydrate-lipid metabolism and antioxidant protection in metabolic syndrome with arterial hypertension and abdominal obesity depended on climatic factors in Azerbaijan. Methods. We examined 16 patients with newly diagnosed arterial hypertension with abdominal obesity on the background of the metabolic syndrome aged 25 to 70 years (16 men). To study the components of carbohydrate, lipid metabolism and antioxidant protection in patients, blood was collected from the cubital vein after a 12-hour fast. The study of the parameters of the general blood test performed on the apparatus Mythic 18 (Switzerland). The levels of glucose, glicohemoglobin, C-peptide, insulin, cholesterol, low-density lipoproteins, high-density lipoproteins, triglycerides, malondialdehyde, and the activity of superoxide dismutase enzymes, catalase, and interleukin-8 studied. Results. The insulin level in the blood plasma of patients compared with the control group showed a significant increase in the studied parameter in this pathology. Despite the fact that glucose and insulin in the control group were 4,58±0,15 mM/l and 16,2±0,6 uU/ml, with this pathology, statistically significantly increased and became 5,58±0,26 mM/l and 18,3±0,7 uU/ml. The content of glucose in patients varied in the reference range. The average value of this parameter was close to the threshold value (5.58±0.26 mM/l), which signals the need to monitor blood sugar levels. Despite the fact that glycohemoglobin did not undergo changes, the content of C-peptide increased compensatory. Compared to the control group, cholesterol increased by 43.5% p <0.001, low-density lipoprotein by 41.3% p <0.001, high-density lipoprotein by 16% p <0.005, triglycerides by 96.6% p <0.001. In practically healthy people, there were no changes in the content of the studied biochemical parameters. Compared with the control group, the content of malonic dialdehyde increased by 253,1%, the activity of the enzyme superoxide dismutase by 36,3%, catalase by 35,4% and interleukin-8 by 69,6%. Conclusion. In the examined patients with arterial hypertension and abdominal obesity with metabolic syndrome, a significant increase in the level of cholesterol, low-density lipoproteins, triglycerides, malondialdehyde and antioxidant enzymes and the proinflammatory cytokine interleukin-8 found.

Keywords

• metabolic syndrome
• glucose
• insulin
• cholesterol
• triglycerides
• ldl
• hdl
• mda
• sod
• catalase
• interleukin-8