Seroprevalence of Crimean-Congo haemorrhagic fever in Indian cattle and buffaloes

Abstract

Background & objectives: Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne viral zoonotic disease of public health importance. Cattle and buffaloes although not showing any clinical symptoms, can be infected by the CCHF virus and act as sources of infection to human beings. The prevalence of CCHF in cattle and buffaloes is important from One health perspective for control of CCHF in humans. Methods: A cross-sectional study was undertaken to ascertain the prevalence of CCHFV in cattle and buffaloes of India. Materials and methods: A total of 804 serum samples from four states of India (Gujarat and Rajasthan: human outbreaks reported; Punjab and Haryana: no outbreak reported) were screened by ELISA test detecting nucleoprotein antibodies of CCHFV. Results: The overall true prevalence was 8.63% (95% CI: 6.76% – 10.9%). The highest prevalence was recorded in Rajasthan (13.24%) followed by Gujarat (8.68%), Haryana (6.84%), and Punjab (6.51%). Prevalence of CCHF was higher in cattle (9.92%) than buffaloes (5.84%); in females (10.87%) than males (4.99%); in adults (10.18%) than young ones (5.66%). Interestingly, higher seropositivity was recorded in indigenous cattle (12.04%) than in exotic and cross-breed cattle (1.69%) which was statistically significant (p=0.001). Interpretation & conclusion: These findings revealed CCHF virus is circulating unnoticed and the prevalence has increased over time which is of public health concern.