Investigation of Anti-inflammatory Effect of Aqueous Extract of Cuminum cyminum L. by Formalin Inflammatory Model in Male Rats

Abstract

Background: Inflammatory pain is caused by tissue inflammation and injury. Formalin is one of most important compounds used to induce inflammation. At the moment, the recognition and development of anti-inflammatory drugs that are naturally occurring have been very much taken into consideration. Cuminum is one of plants with anti-inflammatory potentials. Considering the importance of a more complete understanding of the mechanisms that create and advance inflammation in order to find better, more complete and less complicated ways to improve inflammation and inflammatory pain, much and sometimes intense side effects of chemical treatments, The growing importance of medicinal plants in various medical fields and importance and diverse applications of Cuminum in medical sciences. Objective: The purpose of this study was to evaluate the anti-inflammatory effect of Cuminum aqueous extract in male rats. Method: 36 rats were used in different groups. Aqueous extract of Cuminum fruits was prepared at doses of 200, 500, 1000 mg / kg. Inflammation induced by subcutaneous injection of formalin in animalchr('39')s foot and then, inflammatory pain was evaluated. One-way ANOVA was used to analyze the data. Results: Different doses of the extract reduced the acute and chronic inflammation. The highest reduction effect in the acute phase was related to dose of 200 mg/kg and in the chronic phase, the dose was 1000 mg/kg. Conclusion: aqueous extract of the Cuminum plant has an acute and chronic anti-inflammatory effect, and this effect is dose-dependent.

Keywords

• <i>cuminum cyminum</i> l.
• acute inflammation
• aqueous extract
• chronic inflammation
• formalin