Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation

Yeongjin Baek; Tae-Gyun Woo; Jinsook Ahn; Dukwon Lee; Yonghoon Kwon; Bum-Joon Park; Nam-Chul Ha

doi:10.1038/s42003-022-04017-0

Communications Biology (Oct 2022)

Structural analysis of the overoxidized Cu/Zn-superoxide dismutase in ROS-induced ALS filament formation

Yeongjin Baek,
Tae-Gyun Woo,
Jinsook Ahn,
Dukwon Lee,
Yonghoon Kwon,
Bum-Joon Park,
Nam-Chul Ha

Affiliations

Yeongjin Baek: Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University
Tae-Gyun Woo: Department of Molecular Biology, College of Natural Science, Pusan National University
Jinsook Ahn: Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University
Dukwon Lee: Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University
Yonghoon Kwon: Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University
Bum-Joon Park: Department of Molecular Biology, College of Natural Science, Pusan National University
Nam-Chul Ha: Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, CALS, Seoul National University

DOI: https://doi.org/10.1038/s42003-022-04017-0
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

Characterization of the structure of an overoxidation-mimicking double mutant of superoxide dismutase SOD1 shows the production of more cytotoxic filaments seen in amyotrophic lateral sclerosis (ALS) neurons.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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