Nature Communications (Jan 2019)

IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling

  • Xia Sheng,
  • Hatice Zeynep Nenseth,
  • Su Qu,
  • Omer F. Kuzu,
  • Turid Frahnow,
  • Lukas Simon,
  • Stephanie Greene,
  • Qingping Zeng,
  • Ladan Fazli,
  • Paul S. Rennie,
  • Ian G. Mills,
  • Håvard Danielsen,
  • Fabian Theis,
  • John B. Patterson,
  • Yang Jin,
  • Fahri Saatcioglu

DOI
https://doi.org/10.1038/s41467-018-08152-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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ER stress and UPR are implicated in various cancers. Here, the authors show that one of the canonical UPR pathways, IRE1α-XBP1 regulates c-MYC signaling to promote prostate tumorigenesis, and pharmacological inhibition of IRE1α with MKC8866 inhibits prostate cancer growth and synergizes with clinically used prostate cancer drugs.