Diabetes, Metabolic Syndrome and Obesity (Oct 2024)
Association of Monocyte Chemoattractant Protein-1 (MCP-1) 2518 A/G Polymorphism with Obesity in Korean Type 2 Diabetes Mellitus
Abstract
Sangshin Park,1,* Dong-Hwa Lee,2,* Shinyoung Lee,1 Hyun Jeong Jeon2 1Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea; 2Department of Internal Medicine, Chungbuk National University College of Medicine and Chungbuk National University Hospital, Cheongju, Korea*These authors contributed equally to this workCorrespondence: Hyun Jeong Jeon, Department of Internal Medicine, Chungbuk National University College of Medicine 1 Chungbuk Na-Tional University Hospital, 776, 1Sunhwan-ro, Seowon-gu, Cheongju-si, Chungcheongbuk-do, 28644, South Korea, Tel +82-43-269-6352, Email [email protected]: Monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family, and the MCP-1 2518 A/G gene polymorphism is reported to be correlated with chronic inflammatory diseases, including insulin resistance and metabolic syndrome. However, few studies have investigated the association between MCP-1 gene polymorphisms and obesity in patients with type 2 diabetes mellitus (T2DM). We conducted a retrospective case-control study and evaluated the association between the MCP-1 2518 A/G polymorphism and obesity in Korean patients with T2DM.Patients and Methods: This single-center, retrospective, case-control study enrolled 526 Korean patients with T2DM. Obesity was defined using the body mass index (BMI) with a cutoff level of 25 kg/m2. Polymerase chain reaction-restriction fragment length polymorphism was used to analyze MCP-1 2518 A/G polymorphism; the genotypes was presented as GG, AG, or AA. We compared the MCP-1 2518 A/G polymorphism with the prevalence of diabetic complications, as well as clinical and biochemical characteristics.Results: The obese group had a higher number of females and higher C-peptide, insulin, triglycerides, aspartate transaminase (AST), and alanine transaminase (ALT) levels. The obese group also had a higher prevalence of cardiovascular disease than the non-obese group. The obese group had a higher frequency of the MCP-1 2518 AA genotype and the A allele than the non-obese group. The results of multiple logistic regression analysis showed that the non-G allele of MCP-1 was significantly associated with obesity (odds ratio (OR), 1.888; P=0.016).Conclusion: This study demonstrates that the MCP-1 2518 A/G polymorphism is associated with obesity in Korean patients with T2DM. Further studies involving various ethnic groups are required to validate our results.Keywords: obesity, MCP-1 protein, polymorphism, diabetes mellitus
