Nature Communications (Apr 2017)
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
- Anne E. Justice,
- Thomas W. Winkler,
- Mary F. Feitosa,
- Misa Graff,
- Virginia A. Fisher,
- Kristin Young,
- Llilda Barata,
- Xuan Deng,
- Jacek Czajkowski,
- David Hadley,
- Julius S. Ngwa,
- Tarunveer S. Ahluwalia,
- Audrey Y. Chu,
- Nancy L. Heard-Costa,
- Elise Lim,
- Jeremiah Perez,
- John D. Eicher,
- Zoltán Kutalik,
- Luting Xue,
- Anubha Mahajan,
- Frida Renström,
- Joseph Wu,
- Qibin Qi,
- Shafqat Ahmad,
- Tamuno Alfred,
- Najaf Amin,
- Lawrence F. Bielak,
- Amelie Bonnefond,
- Jennifer Bragg,
- Gemma Cadby,
- Martina Chittani,
- Scott Coggeshall,
- Tanguy Corre,
- Nese Direk,
- Joel Eriksson,
- Krista Fischer,
- Mathias Gorski,
- Marie Neergaard Harder,
- Momoko Horikoshi,
- Tao Huang,
- Jennifer E. Huffman,
- Anne U. Jackson,
- Johanne Marie Justesen,
- Stavroula Kanoni,
- Leena Kinnunen,
- Marcus E. Kleber,
- Pirjo Komulainen,
- Meena Kumari,
- Unhee Lim,
- Jian'an Luan,
- Leo-Pekka Lyytikäinen,
- Massimo Mangino,
- Ani Manichaikul,
- Jonathan Marten,
- Rita P. S. Middelberg,
- Martina Müller-Nurasyid,
- Pau Navarro,
- Louis Pérusse,
- Natalia Pervjakova,
- Cinzia Sarti,
- Albert Vernon Smith,
- Jennifer A. Smith,
- Alena Stančáková,
- Rona J. Strawbridge,
- Heather M. Stringham,
- Yun Ju Sung,
- Toshiko Tanaka,
- Alexander Teumer,
- Stella Trompet,
- Sander W. van der Laan,
- Peter J. van der Most,
- Jana V. Van Vliet-Ostaptchouk,
- Sailaja L. Vedantam,
- Niek Verweij,
- Jacqueline M. Vink,
- Veronique Vitart,
- Ying Wu,
- Loic Yengo,
- Weihua Zhang,
- Jing Hua Zhao,
- Martina E. Zimmermann,
- Niha Zubair,
- Gonçalo R. Abecasis,
- Linda S. Adair,
- Saima Afaq,
- Uzma Afzal,
- Stephan J. L. Bakker,
- Traci M. Bartz,
- John Beilby,
- Richard N. Bergman,
- Sven Bergmann,
- Reiner Biffar,
- John Blangero,
- Eric Boerwinkle,
- Lori L. Bonnycastle,
- Erwin Bottinger,
- Daniele Braga,
- Brendan M. Buckley,
- Steve Buyske,
- Harry Campbell,
- John C. Chambers,
- Francis S. Collins,
- Joanne E. Curran,
- Gert J. de Borst,
- Anton J. M. de Craen,
- Eco J. C. de Geus,
- George Dedoussis,
- Graciela E. Delgado,
- Hester M. den Ruijter,
- Gudny Eiriksdottir,
- Anna L. Eriksson,
- Tõnu Esko,
- Jessica D. Faul,
- Ian Ford,
- Terrence Forrester,
- Karl Gertow,
- Bruna Gigante,
- Nicola Glorioso,
- Jian Gong,
- Harald Grallert,
- Tanja B. Grammer,
- Niels Grarup,
- Saskia Haitjema,
- Göran Hallmans,
- Anders Hamsten,
- Torben Hansen,
- Tamara B. Harris,
- Catharina A. Hartman,
- Maija Hassinen,
- Nicholas D. Hastie,
- Andrew C. Heath,
- Dena Hernandez,
- Lucia Hindorff,
- Lynne J. Hocking,
- Mette Hollensted,
- Oddgeir L. Holmen,
- Georg Homuth,
- Jouke Jan Hottenga,
- Jie Huang,
- Joseph Hung,
- Nina Hutri-Kähönen,
- Erik Ingelsson,
- Alan L. James,
- John-Olov Jansson,
- Marjo-Riitta Jarvelin,
- Min A. Jhun,
- Marit E. Jørgensen,
- Markus Juonala,
- Mika Kähönen,
- Magnus Karlsson,
- Heikki A. Koistinen,
- Ivana Kolcic,
- Genovefa Kolovou,
- Charles Kooperberg,
- Bernhard K. Krämer,
- Johanna Kuusisto,
- Kirsti Kvaløy,
- Timo A. Lakka,
- Claudia Langenberg,
- Lenore J. Launer,
- Karin Leander,
- Nanette R. Lee,
- Lars Lind,
- Cecilia M. Lindgren,
- Allan Linneberg,
- Stephane Lobbens,
- Marie Loh,
- Mattias Lorentzon,
- Robert Luben,
- Gitta Lubke,
- Anja Ludolph-Donislawski,
- Sara Lupoli,
- Pamela A. F. Madden,
- Reija Männikkö,
- Pedro Marques-Vidal,
- Nicholas G. Martin,
- Colin A. McKenzie,
- Barbara McKnight,
- Dan Mellström,
- Cristina Menni,
- Grant W. Montgomery,
- AW (Bill) Musk,
- Narisu Narisu,
- Matthias Nauck,
- Ilja M. Nolte,
- Albertine J. Oldehinkel,
- Matthias Olden,
- Ken K. Ong,
- Sandosh Padmanabhan,
- Patricia A. Peyser,
- Charlotta Pisinger,
- David J. Porteous,
- Olli T. Raitakari,
- Tuomo Rankinen,
- D. C. Rao,
- Laura J. Rasmussen-Torvik,
- Rajesh Rawal,
- Treva Rice,
- Paul M. Ridker,
- Lynda M. Rose,
- Stephanie A. Bien,
- Igor Rudan,
- Serena Sanna,
- Mark A. Sarzynski,
- Naveed Sattar,
- Kai Savonen,
- David Schlessinger,
- Salome Scholtens,
- Claudia Schurmann,
- Robert A. Scott,
- Bengt Sennblad,
- Marten A. Siemelink,
- Günther Silbernagel,
- P Eline Slagboom,
- Harold Snieder,
- Jan A. Staessen,
- David J. Stott,
- Morris A. Swertz,
- Amy J. Swift,
- Kent D. Taylor,
- Bamidele O. Tayo,
- Barbara Thorand,
- Dorothee Thuillier,
- Jaakko Tuomilehto,
- Andre G. Uitterlinden,
- Liesbeth Vandenput,
- Marie-Claude Vohl,
- Henry Völzke,
- Judith M. Vonk,
- Gérard Waeber,
- Melanie Waldenberger,
- R. G. J. Westendorp,
- Sarah Wild,
- Gonneke Willemsen,
- Bruce H. R. Wolffenbuttel,
- Andrew Wong,
- Alan F. Wright,
- Wei Zhao,
- M Carola Zillikens,
- Damiano Baldassarre,
- Beverley Balkau,
- Stefania Bandinelli,
- Carsten A. Böger,
- Dorret I. Boomsma,
- Claude Bouchard,
- Marcel Bruinenberg,
- Daniel I. Chasman,
- Yii-DerIda Chen,
- Peter S. Chines,
- Richard S. Cooper,
- Francesco Cucca,
- Daniele Cusi,
- Ulf de Faire,
- Luigi Ferrucci,
- Paul W. Franks,
- Philippe Froguel,
- Penny Gordon-Larsen,
- Hans- Jörgen Grabe,
- Vilmundur Gudnason,
- Christopher A. Haiman,
- Caroline Hayward,
- Kristian Hveem,
- Andrew D. Johnson,
- J Wouter Jukema,
- Sharon L. R. Kardia,
- Mika Kivimaki,
- Jaspal S. Kooner,
- Diana Kuh,
- Markku Laakso,
- Terho Lehtimäki,
- Loic Le Marchand,
- Winfried März,
- Mark I. McCarthy,
- Andres Metspalu,
- Andrew P. Morris,
- Claes Ohlsson,
- Lyle J. Palmer,
- Gerard Pasterkamp,
- Oluf Pedersen,
- Annette Peters,
- Ulrike Peters,
- Ozren Polasek,
- Bruce M. Psaty,
- Lu Qi,
- Rainer Rauramaa,
- Blair H. Smith,
- Thorkild I. A. Sørensen,
- Konstantin Strauch,
- Henning Tiemeier,
- Elena Tremoli,
- Pim van der Harst,
- Henrik Vestergaard,
- Peter Vollenweider,
- Nicholas J. Wareham,
- David R. Weir,
- John B. Whitfield,
- James F. Wilson,
- Jessica Tyrrell,
- Timothy M. Frayling,
- Inês Barroso,
- Michael Boehnke,
- Panagiotis Deloukas,
- Caroline S. Fox,
- Joel N. Hirschhorn,
- David J. Hunter,
- Tim D. Spector,
- David P. Strachan,
- Cornelia M. van Duijn,
- Iris M. Heid,
- Karen L. Mohlke,
- Jonathan Marchini,
- Ruth J. F. Loos,
- Tuomas O. Kilpeläinen,
- Ching-Ti Liu,
- Ingrid B. Borecki,
- Kari E. North,
- L Adrienne Cupples
Affiliations
- Anne E. Justice
- Department of Epidemiology, University of North Carolina
- Thomas W. Winkler
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Mary F. Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Misa Graff
- Department of Epidemiology, University of North Carolina
- Virginia A. Fisher
- Department of Biostatistics, Boston University School of Public Health
- Kristin Young
- Department of Epidemiology, University of North Carolina
- Llilda Barata
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Xuan Deng
- Department of Biostatistics, Boston University School of Public Health
- Jacek Czajkowski
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- David Hadley
- Population Health Research Institute, St. George's, University of London
- Julius S. Ngwa
- Department of Biostatistics, Boston University School of Public Health
- Tarunveer S. Ahluwalia
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Audrey Y. Chu
- NHLBI Framingham Heart Study
- Nancy L. Heard-Costa
- NHLBI Framingham Heart Study
- Elise Lim
- Department of Biostatistics, Boston University School of Public Health
- Jeremiah Perez
- Department of Biostatistics, Boston University School of Public Health
- John D. Eicher
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
- Zoltán Kutalik
- Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
- Luting Xue
- Department of Biostatistics, Boston University School of Public Health
- Anubha Mahajan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Frida Renström
- Department of Biobank Research, Umeå University
- Joseph Wu
- Department of Biostatistics, Boston University School of Public Health
- Qibin Qi
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Shafqat Ahmad
- Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School
- Tamuno Alfred
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Najaf Amin
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Amelie Bonnefond
- University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
- Jennifer Bragg
- Internal Medicine - Nephrology, University of Michigan
- Gemma Cadby
- Centre for Genetic Origins of Health and Disease, University of Western Australia
- Martina Chittani
- Department of Health Sciences, University of Milan
- Scott Coggeshall
- Department of Biostatistics, University of Washington
- Tanguy Corre
- Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV)
- Nese Direk
- Department of Epidemiology, Erasmus Medical Center
- Joel Eriksson
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Krista Fischer
- Estonian Genome Center, University of Tartu
- Mathias Gorski
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Marie Neergaard Harder
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Momoko Horikoshi
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Tao Huang
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Jennifer E. Huffman
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
- Anne U. Jackson
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Johanne Marie Justesen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Stavroula Kanoni
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Leena Kinnunen
- Department of Health, National Institute for Health and Welfare
- Marcus E. Kleber
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Pirjo Komulainen
- Kuopio Research Institute of Exercise Medicine
- Meena Kumari
- ISER, University of Essex
- Unhee Lim
- Epidemiology Program, University of Hawaii Cancer Center
- Jian'an Luan
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Massimo Mangino
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Ani Manichaikul
- Department of Public Health Sciences, Center for Public Health Genomics and Biostatistics Section, University of Virginia
- Jonathan Marten
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Rita P. S. Middelberg
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Pau Navarro
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Louis Pérusse
- Department of Kinesiology, Faculty of Medicine, Université Laval
- Natalia Pervjakova
- Estonian Genome Center, University of Tartu
- Cinzia Sarti
- Department of Social and Health Care, City of Helsinki
- Albert Vernon Smith
- Icelandic Heart Association
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Alena Stančáková
- Department of Medicine, Institute of Clinical Medicine, University of Eastern Finland
- Rona J. Strawbridge
- Department of Medicine Solna, Cardiovascular Medicine Unit, Karolinska Institutet
- Heather M. Stringham
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Yun Ju Sung
- Division of Biostatistics, Washington University School of Medicine
- Toshiko Tanaka
- Translational Gerontology Branch, National Institute on Aging
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Sander W. van der Laan
- Department of Cardiology, Division Heart & Lungs, Laboratory of Experimental Cardiology, UMC Utrecht
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Jana V. Van Vliet-Ostaptchouk
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Sailaja L. Vedantam
- Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital
- Niek Verweij
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Jacqueline M. Vink
- Department of Biological Psychology, Vrije Universiteit
- Veronique Vitart
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ying Wu
- Department of Genetics, University of North Carolina
- Loic Yengo
- University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
- Weihua Zhang
- Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
- Jing Hua Zhao
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- Martina E. Zimmermann
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Niha Zubair
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Gonçalo R. Abecasis
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Linda S. Adair
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Saima Afaq
- Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
- Uzma Afzal
- Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
- Stephan J. L. Bakker
- Department of Medicine, University Medical Center Groningen, University of Groningen
- Traci M. Bartz
- Department of Biostatistics, University of Washington
- John Beilby
- Busselton Population Medical Research Institute
- Richard N. Bergman
- Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center
- Sven Bergmann
- Department of Computational Biology, University of Lausanne
- Reiner Biffar
- Clinic for Prosthetic Dentistry, Gerostomatology and Material Science, University Medicine Greifswald
- John Blangero
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
- Eric Boerwinkle
- Human Genetics Center, The University of Texas Health Science Center
- Lori L. Bonnycastle
- Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
- Erwin Bottinger
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Daniele Braga
- Department of Health Sciences, University of Milan
- Brendan M. Buckley
- Department of Pharmacology and Therapeutics, University College Cork
- Steve Buyske
- Department of Genetics, Rutgers University
- Harry Campbell
- Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
- John C. Chambers
- Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
- Francis S. Collins
- Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
- Joanne E. Curran
- South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
- Gert J. de Borst
- Department of Vascular Surgery, Division of Surgical Specialties, UMC Utrecht
- Anton J. M. de Craen
- Department of Gerontology and Geriatrics, Leiden University Medical Center
- Eco J. C. de Geus
- Department of Biological Psychology, Vrije Universiteit
- George Dedoussis
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University
- Graciela E. Delgado
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Hester M. den Ruijter
- Department of Cardiology, Division Heart & Lungs, Laboratory of Experimental Cardiology, UMC Utrecht
- Gudny Eiriksdottir
- Icelandic Heart Association
- Anna L. Eriksson
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Tõnu Esko
- Estonian Genome Center, University of Tartu
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Ian Ford
- Robertson Centre for Biostatistics, University of Glasgow
- Terrence Forrester
- Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies
- Karl Gertow
- Department of Medicine Solna, Cardiovascular Medicine Unit, Karolinska Institutet
- Bruna Gigante
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Nicola Glorioso
- Hypertension and Related Disease Centre, AOU-University of Sassari
- Jian Gong
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Harald Grallert
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Tanja B. Grammer
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Niels Grarup
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Saskia Haitjema
- Department of Cardiology, Division Heart & Lungs, Laboratory of Experimental Cardiology, UMC Utrecht
- Göran Hallmans
- Department of Public Health and Clinical Medicine, Section for Nutritional Research, Umeå University
- Anders Hamsten
- Department of Medicine Solna, Cardiovascular Medicine Unit, Karolinska Institutet
- Torben Hansen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Tamara B. Harris
- Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health
- Catharina A. Hartman
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen
- Maija Hassinen
- Kuopio Research Institute of Exercise Medicine
- Nicholas D. Hastie
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Andrew C. Heath
- Department of Psychiatry, Washington University School of Medicine
- Dena Hernandez
- Laboratory of Neurogenetics, National Institute on Aging
- Lucia Hindorff
- Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health
- Lynne J. Hocking
- Institute of Medical Sciences, University of Aberdeen, Foresterhill
- Mette Hollensted
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Oddgeir L. Holmen
- St. Olav Hospital, Trondheim University Hospital
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
- Jouke Jan Hottenga
- Department of Biological Psychology, Vrije Universiteit
- Jie Huang
- Department of Human Genetics, Wellcome Trust Sanger Institute
- Joseph Hung
- School of Medicine and Pharmacology, The University of Western Australia
- Nina Hutri-Kähönen
- Department of Pediatrics, Tampere University Hospital
- Erik Ingelsson
- Department of Medical Sciences, Molecular Epidemiology, Uppsala University
- Alan L. James
- Busselton Population Medical Research Institute
- John-Olov Jansson
- Department of Physiology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London
- Min A. Jhun
- Department of Epidemiology, School of Public Health, University of Michigan
- Marit E. Jørgensen
- Steno Diabetes Center
- Markus Juonala
- Department of Medicine, University of Turku
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Magnus Karlsson
- Department of Orthopedics and Clinical Sciences, Clinical and Molecular Osteoporosis Research Unit, Skåne University Hospital, Lund University
- Heikki A. Koistinen
- Department of Health, National Institute for Health and Welfare
- Ivana Kolcic
- Department of Public Health, Faculty of Medicine, University of Split
- Genovefa Kolovou
- Department of Cardiology, Onassis Cardiac Surgery Center
- Charles Kooperberg
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Bernhard K. Krämer
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Johanna Kuusisto
- Department of Medicine, University of Eastern Finland and Kuopio University Hospital
- Kirsti Kvaløy
- Department of Public Health and Nursing, HUNT Research Centre, Norwegian University of Science and Technology
- Timo A. Lakka
- Kuopio Research Institute of Exercise Medicine
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- Lenore J. Launer
- Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health
- Karin Leander
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Nanette R. Lee
- USC-Office of Population Studies Foundation, Inc., University of San Carlos
- Lars Lind
- Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University
- Cecilia M. Lindgren
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Allan Linneberg
- Research Centre for Prevention and Health, the Capital Region of Denmark
- Stephane Lobbens
- University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
- Marie Loh
- Dept Epidemiology and Biostatistics, School of Public Health, Imperical College London
- Mattias Lorentzon
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Robert Luben
- Department of Public Health and Primary Care, University of Cambridge
- Gitta Lubke
- Department of Psychology, University of Notre Dame
- Anja Ludolph-Donislawski
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Sara Lupoli
- Department of Health Sciences, University of Milan
- Pamela A. F. Madden
- Department of Psychiatry, Washington University School of Medicine
- Reija Männikkö
- Kuopio Research Institute of Exercise Medicine
- Pedro Marques-Vidal
- Department of Medicine, Internal Medicine, Lausanne university hospital (CHUV)
- Nicholas G. Martin
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- Colin A. McKenzie
- Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies
- Barbara McKnight
- Department of Biostatistics, University of Washington
- Dan Mellström
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Cristina Menni
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Grant W. Montgomery
- Molecular Epidemiology, QIMR Berghofer Medical Research Institute
- AW (Bill) Musk
- Busselton Population Medical Research Institute
- Narisu Narisu
- Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
- Matthias Nauck
- Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
- Ilja M. Nolte
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Albertine J. Oldehinkel
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Centre Groningen
- Matthias Olden
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Ken K. Ong
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- Sandosh Padmanabhan
- Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Charlotta Pisinger
- Research Center for Prevention and Health, Glostrup Hospital
- David J. Porteous
- Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
- Olli T. Raitakari
- Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital
- Tuomo Rankinen
- Human Genomics Laboratory, Pennington Biomedical Research Center
- D. C. Rao
- Division of Biostatistics, Washington University School of Medicine
- Laura J. Rasmussen-Torvik
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Rajesh Rawal
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Treva Rice
- Division of Biostatistics, Washington University School of Medicine
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School
- Lynda M. Rose
- Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School
- Stephanie A. Bien
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Igor Rudan
- Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
- Serena Sanna
- Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato
- Mark A. Sarzynski
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Naveed Sattar
- BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine
- Kai Savonen
- Kuopio Research Institute of Exercise Medicine
- David Schlessinger
- Laboratory of Genetics, National Institute on Aging, National Institutes of Health
- Salome Scholtens
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Claudia Schurmann
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Robert A. Scott
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- Bengt Sennblad
- Department of Medicine Solna, Cardiovascular Medicine Unit, Karolinska Institutet
- Marten A. Siemelink
- Department of Cardiology, Division Heart & Lungs, Laboratory of Experimental Cardiology, UMC Utrecht
- Günther Silbernagel
- Division of Angiology, Department of Internal Medicine, Medical University of Graz
- P Eline Slagboom
- Department of Molecular Epidemiology, Leiden University Medical Center
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Jan A. Staessen
- Department of Cardiovascular Science, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven, Campus Sint Rafael
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow
- Morris A. Swertz
- Department of Genetics, University of Groningen, University Medical Center Groningen
- Amy J. Swift
- Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
- Kent D. Taylor
- Center for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center
- Bamidele O. Tayo
- Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago
- Barbara Thorand
- Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
- Dorothee Thuillier
- University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
- Jaakko Tuomilehto
- Research Division, Dasman Diabetes Institute
- Andre G. Uitterlinden
- Department of Epidemiology, Erasmus Medical Center
- Liesbeth Vandenput
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Marie-Claude Vohl
- Institute of Nutrition and Functional Foods, Université Laval
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Judith M. Vonk
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Gérard Waeber
- Department of Medicine, Internal Medicine, Lausanne university hospital (CHUV)
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- R. G. J. Westendorp
- Department of Public Health, and Center for Healthy Ageing, University of Copenhagen
- Sarah Wild
- Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
- Gonneke Willemsen
- Department of Biological Psychology, Vrije Universiteit
- Bruce H. R. Wolffenbuttel
- Department of Endocrinology, University of Groningen, University Medical Center Groningen
- Andrew Wong
- MRC Unit for Lifelong Health and Ageing at UCL
- Alan F. Wright
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Wei Zhao
- Department of Epidemiology, School of Public Health, University of Michigan
- M Carola Zillikens
- Department of Internal Medicine, Erasmus Medical Center
- Damiano Baldassarre
- Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano
- Beverley Balkau
- Inserm U-1018, CESP
- Stefania Bandinelli
- Geriatric Unit, Azienda USL Toscana centro
- Carsten A. Böger
- Department of Nephrology, University Hospital Regensburg
- Dorret I. Boomsma
- Department of Biological Psychology, Vrije Universiteit
- Claude Bouchard
- Human Genomics Laboratory, Pennington Biomedical Research Center
- Marcel Bruinenberg
- Lifelines Cohort Study
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School
- Yii-DerIda Chen
- Los Angeles BioMedical Research Institute and Department of Pediatrics, Institute for Translational Genomics and Population Sciences, Harbor-UCLA
- Peter S. Chines
- Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
- Richard S. Cooper
- Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago
- Francesco Cucca
- Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale Delle Ricerche (CNR), Cittadella Universitaria di Monserrato
- Daniele Cusi
- Sanipedia srl, Bresso (Milano), Italy and Institute of Biomedical Technologies National Centre of Research Segrate
- Ulf de Faire
- Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Luigi Ferrucci
- Translational Gerontology Branch, National Institute on Aging
- Paul W. Franks
- Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University
- Philippe Froguel
- University of Lille, CNRS, Institut Pasteur of Lille, UMR 8199 - EGID
- Penny Gordon-Larsen
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Hans- Jörgen Grabe
- Department of Psychiatry and Psychotherapy, University Medicine Greifswald
- Vilmundur Gudnason
- Icelandic Heart Association
- Christopher A. Haiman
- Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Caroline Hayward
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Kristian Hveem
- Department of Public Health and Nursing, HUNT Research Centre, Norwegian University of Science and Technology
- Andrew D. Johnson
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, The Framingham Heart Study
- J Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Mika Kivimaki
- Department of Epidemiology and Public Health, UCL
- Jaspal S. Kooner
- Cardiology, Ealing Hospital NHS Trust
- Diana Kuh
- MRC Unit for Lifelong Health and Ageing at UCL
- Markku Laakso
- Department of Medicine, University of Eastern Finland and Kuopio University Hospital
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Loic Le Marchand
- Epidemiology Program, University of Hawaii Cancer Center
- Winfried März
- Synlab Academy, Synlab Services GmbH
- Mark I. McCarthy
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Andres Metspalu
- Estonian Genome Center, University of Tartu
- Andrew P. Morris
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Claes Ohlsson
- Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg
- Lyle J. Palmer
- School of Public Health, University of Adelaide
- Gerard Pasterkamp
- Department of Cardiology, Division Heart & Lungs, Laboratory of Experimental Cardiology, UMC Utrecht
- Oluf Pedersen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Annette Peters
- Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health
- Ulrike Peters
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Ozren Polasek
- Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh
- Bruce M. Psaty
- Department of Medicine, University of Washington
- Lu Qi
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Rainer Rauramaa
- Kuopio Research Institute of Exercise Medicine
- Blair H. Smith
- Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
- Thorkild I. A. Sørensen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health
- Henning Tiemeier
- Department of Psychiatry Erasmus Medical Center
- Elena Tremoli
- Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano
- Pim van der Harst
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Henrik Vestergaard
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Peter Vollenweider
- Department of Medicine, Internal Medicine, Lausanne university hospital (CHUV)
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science
- David R. Weir
- Survey Research Center, Institute for Social Research, University of Michigan
- John B. Whitfield
- Genetic Epidemiology, QIMR Berghofer Medical Research Institute
- James F. Wilson
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Jessica Tyrrell
- Genetics of Complex Traits, University of Exeter Medical School, RILD Building University of Exeter
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Inês Barroso
- Wellcome Trust Sanger Institute
- Michael Boehnke
- Department of Biostatistics and Center for Statistical Genetics, University of Michigan
- Panagiotis Deloukas
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Caroline S. Fox
- NHLBI Framingham Heart Study
- Joel N. Hirschhorn
- Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital
- David J. Hunter
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology, King’s College London
- David P. Strachan
- Population Health Research Institute, St. George's, University of London
- Cornelia M. van Duijn
- Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center
- Iris M. Heid
- Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Jonathan Marchini
- Department of Statistics, University of Oxford
- Ruth J. F. Loos
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Tuomas O. Kilpeläinen
- The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen
- Ching-Ti Liu
- Department of Biostatistics, Boston University School of Public Health
- Ingrid B. Borecki
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Kari E. North
- Department of Epidemiology, University of North Carolina
- L Adrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- DOI
- https://doi.org/10.1038/ncomms14977
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find that smoking may alter genetic susceptibilities.
