The Correlation Between sP-Selectin and Platelet Count in COVID-19 Patients in Referral Hospital, West Java Indonesia

Abstract

Delita Prihatni,1 Frany Charisma Budianto,1 Basti Andriyoko,1 Suryarini Trisa2 1Clinical Pathology Department, Medical Faculty of Padjadjaran University, Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 2Depati Hamzah Hospital, Bangka Belitung, IndonesiaCorrespondence: Delita Prihatni, Hasan Sadikin Hospital, Jln. Pasteur No. 38, Bandung, West Java, Indonesia, Tel [phone], Email [email protected]: sP-selectin is a glycoprotein located in α granules of platelet and endothelial’s Weibel Palade body, as expression to platelet activation and endothelial cell stimulation by SARS-CoV-2 binding with ACE2 receptor. Consumptive thrombocytopenia is also related to platelet activation. Elevation of sP-selectin and thrombocytopenia are related to COVID-19 complication and often correlated with severity of COVID-19.Purpose: Assess the correlation between sP-selectin and platelet in COVID-19 patients at intensive care and non-intensive care.Patients and Methods: The study population was hospitalized COVID-19 patients confirmed by Real-Time PCR that underwent platelet examination within 48 hours upon admission, divided into intensive care and non-intensive care group. sP-selectin examination using ELISA methods. Platelet cell count and sP-selectin divided based on normal reference range.Results: The subjects consist of 24 were in intensive care, 25 were in non-intensive care group. A 66.7% of subject in intensive care group has an elevation in sP-selection (> 44.0 ng/mL). Thrombocytopenia was significantly correlated with intensive group (r =− 0.32, p 44.0ng/mL was not correlated with the intensive and non-intensive group. Platelet and sP-selectin were not correlated with each other.Conclusion: Thrombocytopenia is able to induce the expression of sP-selectin.Keywords: COVID-19, sP-selectin, platelet, thrombocytopenia

Keywords

• covid-19
• sp-selectin
• platelet
• thrombocytopenia.