Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

Xu Wang; Jonathan Wilhelm; Wei Li; Suxin Li; Zhaohui Wang; Gang Huang; Jian Wang; Houliang Tang; Sina Khorsandi; Zhichen Sun; Bret Evers; Jinming Gao

doi:10.1038/s41467-020-19651-7

Nature Communications (Nov 2020)

Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window

Xu Wang,
Jonathan Wilhelm,
Wei Li,
Suxin Li,
Zhaohui Wang,
Gang Huang,
Jian Wang,
Houliang Tang,
Sina Khorsandi,
Zhichen Sun,
Bret Evers,
Jinming Gao

Affiliations

Xu Wang: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Jonathan Wilhelm: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Wei Li: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Suxin Li: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Zhaohui Wang: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Gang Huang: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Jian Wang: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Houliang Tang: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Sina Khorsandi: Department of Radiology, University of Texas Southwestern Medical Center
Zhichen Sun: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center
Bret Evers: Department of Pathology and Ophthalmology, University of Texas Southwestern Medical Center
Jinming Gao: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-020-19651-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

Read online

Stimuli-responsive nanomaterials offer the opportunity to exploit nanoscale cooperativity to improve the precision of diagnostic or therapeutic outcomes. Here, the authors report the design, synthesis and characterization of a series of degradable ultra-pH sensitive polymers that amplify small acidic pH changes to efficacious therapeutic outputs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal