Nature Communications (Jan 2020)
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
- Thorunn A. Olafsdottir,
- Fannar Theodors,
- Kristbjorg Bjarnadottir,
- Unnur Steina Bjornsdottir,
- Arna B. Agustsdottir,
- Olafur A. Stefansson,
- Erna V. Ivarsdottir,
- Jon K. Sigurdsson,
- Stefania Benonisdottir,
- Gudmundur I. Eyjolfsson,
- David Gislason,
- Thorarinn Gislason,
- Steinunn Guðmundsdóttir,
- Arnaldur Gylfason,
- Bjarni V. Halldorsson,
- Gisli H. Halldorsson,
- Thorhildur Juliusdottir,
- Anna M. Kristinsdottir,
- Dora Ludviksdottir,
- Bjorn R. Ludviksson,
- Gisli Masson,
- Kristjan Norland,
- Pall T. Onundarson,
- Isleifur Olafsson,
- Olof Sigurdardottir,
- Lilja Stefansdottir,
- Gardar Sveinbjornsson,
- Vinicius Tragante,
- Daniel F. Gudbjartsson,
- Gudmar Thorleifsson,
- Patrick Sulem,
- Unnur Thorsteinsdottir,
- Gudmundur L. Norddahl,
- Ingileif Jonsdottir,
- Kari Stefansson
Affiliations
- Thorunn A. Olafsdottir
- deCODE genetics/Amgen, Inc.
- Fannar Theodors
- deCODE genetics/Amgen, Inc.
- Kristbjorg Bjarnadottir
- deCODE genetics/Amgen, Inc.
- Unnur Steina Bjornsdottir
- Department of Medicine, Landspitali, The National University Hospital of Iceland
- Arna B. Agustsdottir
- deCODE genetics/Amgen, Inc.
- Olafur A. Stefansson
- deCODE genetics/Amgen, Inc.
- Erna V. Ivarsdottir
- deCODE genetics/Amgen, Inc.
- Jon K. Sigurdsson
- deCODE genetics/Amgen, Inc.
- Stefania Benonisdottir
- deCODE genetics/Amgen, Inc.
- Gudmundur I. Eyjolfsson
- The Laboratory in Mjodd, RAM
- David Gislason
- The Medical Center Mjodd
- Thorarinn Gislason
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Steinunn Guðmundsdóttir
- deCODE genetics/Amgen, Inc.
- Arnaldur Gylfason
- deCODE genetics/Amgen, Inc.
- Bjarni V. Halldorsson
- deCODE genetics/Amgen, Inc.
- Gisli H. Halldorsson
- deCODE genetics/Amgen, Inc.
- Thorhildur Juliusdottir
- deCODE genetics/Amgen, Inc.
- Anna M. Kristinsdottir
- deCODE genetics/Amgen, Inc.
- Dora Ludviksdottir
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Bjorn R. Ludviksson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Gisli Masson
- deCODE genetics/Amgen, Inc.
- Kristjan Norland
- deCODE genetics/Amgen, Inc.
- Pall T. Onundarson
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali, The National University Hospital of Iceland
- Olof Sigurdardottir
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Lilja Stefansdottir
- deCODE genetics/Amgen, Inc.
- Gardar Sveinbjornsson
- deCODE genetics/Amgen, Inc.
- Vinicius Tragante
- deCODE genetics/Amgen, Inc.
- Daniel F. Gudbjartsson
- deCODE genetics/Amgen, Inc.
- Gudmar Thorleifsson
- deCODE genetics/Amgen, Inc.
- Patrick Sulem
- deCODE genetics/Amgen, Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen, Inc.
- Gudmundur L. Norddahl
- deCODE genetics/Amgen, Inc.
- Ingileif Jonsdottir
- deCODE genetics/Amgen, Inc.
- Kari Stefansson
- deCODE genetics/Amgen, Inc.
- DOI
- https://doi.org/10.1038/s41467-019-14144-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8.
