Journal of the Dow University of Health Sciences (Aug 2014)
Frequency of Prediabetes, Raised BMI and Low Plasma HDL-Cholesterol in Offspring of Diabetes
Abstract
Background: World wide approximately 470 millions people are getting affected by a prediabetic state. Risk of diabetes is doubled when there is a family history of diabetes (FHD) in parents. Pakistan is ranked at 6thplace amongst the top 10 countries of the world including India, China and USA in the report predicting cases of diabetes for the future. Prediabetes is a term for impaired fasting glucose [IFG]. Aims/hypothesis: A positive (FHD) is associated with increased risk for raised BMI, prediabetic state and low HDL (High density lipoprotein). Methodology: This was a cross-sectional study. Young healthy subjects between 18- 24 years were classified according to familial history of T2DM as single diabetic parent (SDP), with both diabetic parents (BDP) and with no diabetic parents (NDP). BMI, Plasma Cholesterol, Plasma HDL and Fasting plasma glucose was assessed. Results: Significantly higher statistical values were observed in the body weight of offspring of both diabetics as compared to NDP and SDP. The mean values for Fasting plasma glucose for BDP, SDP and NDP are 4.73±0.75, 4.65±0.47 and 4.61 ±0.24 respectively. Mean values for BMI among BDP were 25.58 ±5.15, 22.26±6.80 in SDP and NDP it was 21.02 ±6.19 and 4.91±6.78. IFG was detected 5.1% and 4.2 % in offspring of BDP and SDP. Low HDL Cholesterol was found to be 4.2%,12.9% and 10.3% in BDP, SDP and NDP. Conclusion: Prediabetes, raised BMI and low HDL-Cholesterol was reported in positive FHD in offspring suggesting that these parameters may be the risk factors of development of diabetes and cardiovascular diseases in future life.
