Nature Communications (Jul 2018)
TCR signal strength controls thymic differentiation of iNKT cell subsets
- Kathryn D. Tuttle,
- S. Harsha Krovi,
- Jingjing Zhang,
- Romain Bedel,
- Laura Harmacek,
- Lisa K. Peterson,
- Leonard L. Dragone,
- Adam Lefferts,
- Catherine Halluszczak,
- Kent Riemondy,
- Jay R. Hesselberth,
- Anjana Rao,
- Brian P. O’Connor,
- Philippa Marrack,
- James Scott-Browne,
- Laurent Gapin
Affiliations
- Kathryn D. Tuttle
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- S. Harsha Krovi
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Jingjing Zhang
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Romain Bedel
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Laura Harmacek
- Center for Genes, Environment, and Health, Department of Biomedical Research, National Jewish Health
- Lisa K. Peterson
- Department of Pediatrics, National Jewish Health
- Leonard L. Dragone
- Department of Pediatrics, National Jewish Health
- Adam Lefferts
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Catherine Halluszczak
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- Kent Riemondy
- RNA Bioscience Initiative, University of Colorado School of Medicine
- Jay R. Hesselberth
- RNA Bioscience Initiative, University of Colorado School of Medicine
- Anjana Rao
- La Jolla Institute
- Brian P. O’Connor
- Center for Genes, Environment, and Health, Department of Biomedical Research, National Jewish Health
- Philippa Marrack
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- James Scott-Browne
- La Jolla Institute
- Laurent Gapin
- Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus
- DOI
- https://doi.org/10.1038/s41467-018-05026-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.
