Nature Communications (Nov 2021)
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
- Eva G. Álvarez,
- Jonas Demeulemeester,
- Paula Otero,
- Clemency Jolly,
- Daniel García-Souto,
- Ana Pequeño-Valtierra,
- Jorge Zamora,
- Marta Tojo,
- Javier Temes,
- Adrian Baez-Ortega,
- Bernardo Rodriguez-Martin,
- Ana Oitaben,
- Alicia L. Bruzos,
- Mónica Martínez-Fernández,
- Kerstin Haase,
- Sonia Zumalave,
- Rosanna Abal,
- Jorge Rodríguez-Castro,
- Aitor Rodriguez-Casanova,
- Angel Diaz-Lagares,
- Yilong Li,
- Keiran M. Raine,
- Adam P. Butler,
- Iago Otero,
- Atsushi Ono,
- Hiroshi Aikata,
- Kazuaki Chayama,
- Masaki Ueno,
- Shinya Hayami,
- Hiroki Yamaue,
- Kazuhiro Maejima,
- Miguel G. Blanco,
- Xavier Forns,
- Carmen Rivas,
- Juan Ruiz-Bañobre,
- Sofía Pérez-del-Pulgar,
- Raúl Torres-Ruiz,
- Sandra Rodriguez-Perales,
- Urtzi Garaigorta,
- Peter J. Campbell,
- Hidewaki Nakagawa,
- Peter Van Loo,
- Jose M. C. Tubio
Affiliations
- Eva G. Álvarez
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Jonas Demeulemeester
- The Francis Crick Institute
- Paula Otero
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Clemency Jolly
- The Francis Crick Institute
- Daniel García-Souto
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Ana Pequeño-Valtierra
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Jorge Zamora
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Marta Tojo
- The Biomedical Research Centre (CINBIO), Universidade de Vigo
- Javier Temes
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Adrian Baez-Ortega
- Department of Veterinary Medicine, University of Cambridge
- Bernardo Rodriguez-Martin
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Ana Oitaben
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Alicia L. Bruzos
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Mónica Martínez-Fernández
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Kerstin Haase
- The Francis Crick Institute
- Sonia Zumalave
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Rosanna Abal
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Jorge Rodríguez-Castro
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Aitor Rodriguez-Casanova
- Cancer Epigenomics, Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago de Compostela (CHUS/SERGAS)
- Angel Diaz-Lagares
- Cancer Epigenomics, Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago (IDIS), University Clinical Hospital of Santiago de Compostela (CHUS/SERGAS)
- Yilong Li
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Keiran M. Raine
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Adam P. Butler
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Iago Otero
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Atsushi Ono
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Hiroshi Aikata
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Kazuaki Chayama
- Collaborative Research Laboratory of Medical Innovation, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Masaki Ueno
- Department of Surgery II, Wakayama Medical University
- Shinya Hayami
- Department of Surgery II, Wakayama Medical University
- Hiroki Yamaue
- Department of Surgery II, Wakayama Medical University
- Kazuhiro Maejima
- RIKEN Center for Integrative Medical Sciences
- Miguel G. Blanco
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Xavier Forns
- Liver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERehd
- Carmen Rivas
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Juan Ruiz-Bañobre
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- Sofía Pérez-del-Pulgar
- Liver Unit, Hospital Clínic, University of Barcelona, IDIBAPS, CIBERehd
- Raúl Torres-Ruiz
- Molecular Cytogenetics and Genome Engineering Group, Centro Nacional de Investigaciones Oncológicas (CNIO)
- Sandra Rodriguez-Perales
- Molecular Cytogenetics and Genome Engineering Group, Centro Nacional de Investigaciones Oncológicas (CNIO)
- Urtzi Garaigorta
- Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología – Consejo Superior de Investigaciones Científicas (CNB – CSIC)
- Peter J. Campbell
- Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton
- Hidewaki Nakagawa
- RIKEN Center for Integrative Medical Sciences
- Peter Van Loo
- The Francis Crick Institute
- Jose M. C. Tubio
- Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela
- DOI
- https://doi.org/10.1038/s41467-021-26805-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations induced by HBV insertions.
