Frontiers in Neurology (Apr 2020)
Impaired Structural Network Properties Caused by White Matter Hyperintensity Related to Cognitive Decline
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Junyi Ma,
- Junyi Ma,
- Junyi Ma,
- Junyi Ma,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Pengfei Shao,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Hengheng Xu,
- Bing Zhang,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Meijuan Zhang,
- Meijuan Zhang,
- Meijuan Zhang,
- Meijuan Zhang
Affiliations
- Dan Yang
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Dan Yang
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Lili Huang
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Lili Huang
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Caimei Luo
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Caimei Luo
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Mengchun Li
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Mengchun Li
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Ruomeng Qin
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Ruomeng Qin
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Ruomeng Qin
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Ruomeng Qin
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Junyi Ma
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Junyi Ma
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Junyi Ma
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Junyi Ma
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Pengfei Shao
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Pengfei Shao
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Pengfei Shao
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Pengfei Shao
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Hengheng Xu
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Hengheng Xu
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Hengheng Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Hengheng Xu
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Bing Zhang
- Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
- Yun Xu
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Yun Xu
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Meijuan Zhang
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Meijuan Zhang
- Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Meijuan Zhang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Meijuan Zhang
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- DOI
- https://doi.org/10.3389/fneur.2020.00250
- Journal volume & issue
-
Vol. 11
Abstract
Purpose: There is a high correlation between white matter hyperintensity (WMH) and cognitive impairment (CI) in elderly people. However, not all WMH will develop into CI, and the potential mechanism of WMH-related CI is still unclear. This study aimed to investigate the topological properties of white matter structural network in WMH-related CI.Methods: Forty-one WMH subjects with CI (WMH-CI), 42 WMH subjects without CI (WMH-no-CI), and 52 elderly healthy controls (HC) were recruited. Diffusion tensor imaging (DTI) fiber tractography and graph theoretical analysis were applied to construct the structural network. We compared network properties and clinical features among the three groups. Multiple linear regression analysis was performed to investigate the relationships among WMH volumes, impaired network properties, and cognitive functions in the WMH-CI group.Results: Compared with the controls, both WMH groups showed decreased network strength, global efficiency, and increased characteristic path length (Lp) at the level of the whole brain. The WMH-CI group displayed more profound impairments of nodal efficiency and nodal path length (NLp) within multiple regions including precentral, cingulate, and medial temporal gyrus. The disrupted network properties were associated with CI and WMH burdens in the WMH-CI group. Furthermore, a mediation effect of NLp in the left inferior frontal gyrus was observed for the association between periventricular WMH (PWMH) and memory deficit.Conclusions: Brain structural network in WMH-CI is significantly disturbed, and this disturbance is related to the severity of WMH and CI. Increased NLp in the left opercular part of inferior frontal gyrus (IFGoperc.L) was shown to be a mediation framework between PWMH and WMH-related memory, which shed light on investigating the underlying mechanisms of CI caused by WMH.
Keywords
- white matter hyperintensity
- cognitive impairment
- white matter network
- graph theoretical analysis
- diffusion tensor imaging (DTI)
