Alpha-adducin 1 (rs4961) gene and its expression associated with sodium sensitivity in hypertensive patients: a cohort study in the western Ukrainian population

Abstract

Objective. The aim of this study was to evaluate the association of the α-adducin-1 gene (ADD1) (Gly460Trp [rs4961]) polymorphism and its expression in association with renal dysfunction and sodium sensitivity in hypertensive patients in western Ukrainian population.

Keywords

• arterial hypertension
• alpha-adducin (rs4961) gene
• sodium sensitivity
• sodium resistance
• chronic kidney disease
• metabolism
• genes expression
• transcriptional activity