Nature Communications (Oct 2021)
Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
- Zhangyuan Pan,
- Yuelin Yao,
- Hongwei Yin,
- Zexi Cai,
- Ying Wang,
- Lijing Bai,
- Colin Kern,
- Michelle Halstead,
- Ganrea Chanthavixay,
- Nares Trakooljul,
- Klaus Wimmers,
- Goutam Sahana,
- Guosheng Su,
- Mogens Sandø Lund,
- Merete Fredholm,
- Peter Karlskov-Mortensen,
- Catherine W. Ernst,
- Pablo Ross,
- Christopher K. Tuggle,
- Lingzhao Fang,
- Huaijun Zhou
Affiliations
- Zhangyuan Pan
- Department of Animal Science, University of California, Davis
- Yuelin Yao
- MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine, The University of Edinburgh
- Hongwei Yin
- Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences
- Zexi Cai
- Center for Quantitative Genetics and Genomics, Faculty of Technical Sciences, Aarhus University
- Ying Wang
- Department of Animal Science, University of California, Davis
- Lijing Bai
- Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences
- Colin Kern
- Department of Animal Science, University of California, Davis
- Michelle Halstead
- Department of Animal Science, University of California, Davis
- Ganrea Chanthavixay
- Department of Animal Science, University of California, Davis
- Nares Trakooljul
- Leibniz-Institute for Farm Animal Biology
- Klaus Wimmers
- Leibniz-Institute for Farm Animal Biology
- Goutam Sahana
- Center for Quantitative Genetics and Genomics, Faculty of Technical Sciences, Aarhus University
- Guosheng Su
- Center for Quantitative Genetics and Genomics, Faculty of Technical Sciences, Aarhus University
- Mogens Sandø Lund
- Center for Quantitative Genetics and Genomics, Faculty of Technical Sciences, Aarhus University
- Merete Fredholm
- Animal Genetics, Bioinformatics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen
- Peter Karlskov-Mortensen
- Animal Genetics, Bioinformatics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen
- Catherine W. Ernst
- Department of Animal Science, Michigan State University
- Pablo Ross
- Department of Animal Science, University of California, Davis
- Christopher K. Tuggle
- Department of Animal Science, Iowa State University
- Lingzhao Fang
- MRC Human Genetics Unit at the Institute of Genetics and Molecular Medicine, The University of Edinburgh
- Huaijun Zhou
- Department of Animal Science, University of California, Davis
- DOI
- https://doi.org/10.1038/s41467-021-26153-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elements across mouse and human tissues.
