Discovery of a Diaminopyrimidine FLT3 Inhibitor Active against Acute Myeloid Leukemia

• Jamie A. Jarusiewicz,
• Jae Yoon Jeon,
• Michele C. Connelly,
• Yizhe Chen,
• Lei Yang,
• Sharyn D. Baker,
• R. Kiplin Guy

Affiliations

Jamie A. Jarusiewicz

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Jae Yoon Jeon

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States

Michele C. Connelly

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Yizhe Chen

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Lei Yang

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States

Sharyn D. Baker

Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States

R. Kiplin Guy

Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States