JPhys Materials (Jan 2023)
Roadmap on nanomedicine for the central nervous system
- Gianni Ciofani,
- Marco Campisi,
- Clara Mattu,
- Roger D Kamm,
- Valeria Chiono,
- Aji Alex Moothedathu Raynold,
- João S Freitas,
- Eugenio Redolfi Riva,
- Silvestro Micera,
- Carlotta Pucci,
- Fernando Novio,
- Julia Lorenzo,
- Daniel Ruiz-Molina,
- Giulia Sierri,
- Francesca Re,
- Hannah Wunderlich,
- Prachi Kumari,
- Kristen L Kozielski,
- Mounia Chami,
- Attilio Marino,
- Lino Ferreira
Affiliations
- Gianni Ciofani
- ORCiD
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia , Pontedera, Italy
- Marco Campisi
- Department of Mechanical and Aerospace Engineering, Politecnico di Torino , Torino, Italy; Centro 3R (Interuniversity Center for the Promotion of 3Rs Principles in Teaching and Research) , Italy; Department of Medical Oncology, Dana–Farber Cancer Institute , Boston, MA, United States of America
- Clara Mattu
- Department of Mechanical and Aerospace Engineering, Politecnico di Torino , Torino, Italy; Centro 3R (Interuniversity Center for the Promotion of 3Rs Principles in Teaching and Research) , Italy
- Roger D Kamm
- ORCiD
- Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, MA, United States of America; Department of Mechanical Engineering, Massachusetts Institute of Technology , Cambridge, MA, United States of America
- Valeria Chiono
- ORCiD
- Department of Mechanical and Aerospace Engineering, Politecnico di Torino , Torino, Italy; Centro 3R (Interuniversity Center for the Promotion of 3Rs Principles in Teaching and Research) , Italy
- Aji Alex Moothedathu Raynold
- Center for Neuroscience and Cell Biology, University of Coimbra , Coimbra, Portugal
- João S Freitas
- Faculty of Medicine, University of Coimbra , Coimbra, Portugal
- Eugenio Redolfi Riva
- The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna , Pontedera, Italy
- Silvestro Micera
- The BioRobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna , Pontedera, Italy; Centre for Neuroprosthetics and Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne , Lausanne, Switzerland
- Carlotta Pucci
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia , Pontedera, Italy
- Fernando Novio
- CSIC and BIST, Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2) , Barcelona, Spain; Departament de Química, Universitat Autònoma de Barcelona , Barcelona, Spain
- Julia Lorenzo
- ORCiD
- Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona , Barcelona, Spain; Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona , Barcelona, Spain
- Daniel Ruiz-Molina
- ORCiD
- CSIC and BIST, Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2) , Barcelona, Spain
- Giulia Sierri
- School of Medicine and Surgery, University of Milano-Bicocca , Milano, Italy
- Francesca Re
- School of Medicine and Surgery, University of Milano-Bicocca , Milano, Italy
- Hannah Wunderlich
- School of Computation, Information and Technology, Technical University of Munich , Munich, Germany
- Prachi Kumari
- School of Computation, Information and Technology, Technical University of Munich , Munich, Germany
- Kristen L Kozielski
- ORCiD
- School of Computation, Information and Technology, Technical University of Munich , Munich, Germany
- Mounia Chami
- ORCiD
- Institut of Molecular and Cellular Pharmacology, Laboratory of Excellence DistALZ, Université Côte d’Azur, INSERM, CNRS , Valbonne, France
- Attilio Marino
- Smart Bio-Interfaces, Istituto Italiano di Tecnologia , Pontedera, Italy
- Lino Ferreira
- ORCiD
- Center for Neuroscience and Cell Biology, University of Coimbra , Coimbra, Portugal; Faculty of Medicine, University of Coimbra , Coimbra, Portugal
- DOI
- https://doi.org/10.1088/2515-7639/acab88
- Journal volume & issue
-
Vol. 6,
no. 2
p. 022501
Abstract
In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.
Keywords
