Multifunctional nanomaterials-enhanced synergistic sono-phototherapy: Breaking the limitation of monotherapy

Jinxia Zhai; Hong Yang; Zhengao Wang; Yangfan Li; Chengyun Ning

Smart Materials in Medicine (Jan 2022)

Multifunctional nanomaterials-enhanced synergistic sono-phototherapy: Breaking the limitation of monotherapy

Jinxia Zhai,
Hong Yang,
Zhengao Wang,
Yangfan Li,
Chengyun Ning

Affiliations

Jinxia Zhai: School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, Guangzhou, 510641, China
Hong Yang: School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, Guangzhou, 510641, China
Zhengao Wang: School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, Guangzhou, 510641, China
Yangfan Li: School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, Guangzhou, 510641, China
Chengyun Ning: School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, Guangzhou, 510641, China; Sino-Singapore International Joint Research Institute (SSIJRI), Guangzhou, 510000, China; Corresponding author. School of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China.

Journal volume & issue: Vol. 3
pp. 315 – 328

Abstract

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As minimally or non-invasive therapeutic modalities for cancer treatment, phototherapy and sonotherapy have become a new trend for biomedicine because these treatments can only target the cancer cells while leaving the normal tissue undamaged and intact. However, single phototherapy or sonotherapy can obtain effective clinical effects only when the dose of nanomaterials responding to light and ultrasound is high enough. Therefore, it is significant to develop or explore new multifunctional nanomaterials that can simultaneously respond to ultrasound and light to enhance synergistic sono-phototherapy in the clinical cancer treatment. In this review, we summarize the recent developments of multifunctional nanomaterials responding to ultrasound and light, including organic nanomaterials modified by porphyrin and its derivatives, indocyanine green, etc., and inorganic nanomaterials such as titanium dioxide and inorganic piezoelectric nanomaterials. We further elaborate the latest research progress about these multifunctional nanomaterials in the cancer treatment. Particularly, the inorganic piezoelectric nanomaterials can generate a built-in electric field under ultrasound to adjust the separation of photogenerated carriers, which has potential applications to construct multifunctional nanomaterials and enhance tumor therapeutic effects.

Published in Smart Materials in Medicine

ISSN: 2590-1834 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology
Website: https://www.keaipublishing.com/en/journals/smart-materials-in-medicine/

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