Emerging Infectious Diseases (Sep 2020)

Fatal Measles Inclusion-Body Encephalitis in Adult with Untreated AIDS, France

  • Christophe Rodriguez,
  • Meriadeg Ar Gouilh,
  • Nicolas Weiss,
  • Sébastian Stroer,
  • Karima Mokhtari,
  • Danielle Seilhean,
  • Bertrand Mathon,
  • Vanessa Demontant,
  • Melissa N’Debi,
  • Guillaume Gricourt,
  • Paul-Louis Woerther,
  • Jean-Michel Pawlotsky,
  • Karl Stefic,
  • Julien Marlet,
  • Pierre-François Dequin,
  • Antoine Guillon,
  • Valérie Pourcher,
  • David Boutolleau,
  • Astrid Vabret,
  • Sonia Burrel

DOI
https://doi.org/10.3201/eid2609.200366
Journal volume & issue
Vol. 26, no. 9
pp. 2231 – 2234

Abstract

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We report a fatal case of measles inclusion-body encephalitis occurring in a woman from Romania with AIDS. After an extensive but unsuccessful diagnostic evaluation, a pan-pathogen shotgun metagenomic approach revealed a measles virus infection. We identified no mutations previously associated with neurovirulence.

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