Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Alexander C. Partin; Tri D. Ngo; Emily Herrell; Byung-Cheon Jeong; Gary Hon; Yunsun Nam

doi:10.1038/s41467-017-01713-y

Nature Communications (Nov 2017)

Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs

Alexander C. Partin,
Tri D. Ngo,
Emily Herrell,
Byung-Cheon Jeong,
Gary Hon,
Yunsun Nam

Affiliations

Alexander C. Partin: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Tri D. Ngo: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Emily Herrell: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Byung-Cheon Jeong: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Gary Hon: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center
Yunsun Nam: Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-017-01713-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Drosha and DGCR8 constitute the core Microprocessor complex, which processes primary microRNAs (pri-miRs) into mature microRNAs. Here the authors show that heme is essential for the proper processing of pri-miRs by Drosha-DGCR8, and the molecular mechanism by which heme enhances processing fidelity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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