The Effects of <i>Angelica ternata</i> Extract from Kyrgyzstan on the Formation of <i>Candida albicans</i> ATCC 10231 Biofilms

Abstract

The therapeutic potential of Angelica ternata extract was tested against biofilm-associated fungi Candida albicans. Such an extract with a 1.896 ± 0.071% per 1 mL rutin content of flavonoids can reliably suppress the formation of biofilms of pathogenic yeast-like fungi up to 76.6%. The herbal medicine has a significant effect on the initiation, adhesion, and development of biofilms. If the extract is added to a developed biofilm, it has a significant effect on the matrix. As a result, the “glue” between the cells is washed out and they are more easily washed away from the well of the microplate to which they are attached. In this case, the optical density of the biofilm is halved (50.5%).

Keywords

• <i>Candida albicans</i>
• biofilms
• extracellular matrix
• <i>Angelica ternate</i>
• flavonoids