Communications Biology (Mar 2023)
Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging
- Alejandro Sola-García,
- María Ángeles Cáliz-Molina,
- Isabel Espadas,
- Michael Petr,
- Concepción Panadero-Morón,
- Daniel González-Morán,
- María Eugenia Martín-Vázquez,
- Álvaro Jesús Narbona-Pérez,
- Livia López-Noriega,
- Guillermo Martínez-Corrales,
- Raúl López-Fernández-Sobrino,
- Lina M. Carmona-Marin,
- Enrique Martínez-Force,
- Oscar Yanes,
- Maria Vinaixa,
- Daniel López-López,
- José Carlos Reyes,
- Joaquín Dopazo,
- Franz Martín,
- Benoit R. Gauthier,
- Morten Scheibye-Knudsen,
- Vivian Capilla-González,
- Alejandro Martín-Montalvo
Affiliations
- Alejandro Sola-García
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- María Ángeles Cáliz-Molina
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Isabel Espadas
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Michael Petr
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen
- Concepción Panadero-Morón
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Daniel González-Morán
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- María Eugenia Martín-Vázquez
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Álvaro Jesús Narbona-Pérez
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Livia López-Noriega
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Guillermo Martínez-Corrales
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Raúl López-Fernández-Sobrino
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Lina M. Carmona-Marin
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen
- Enrique Martínez-Force
- Instituto de la Grasa (CSIC), Universidad Pablo de Olavide
- Oscar Yanes
- Universitat Rovira i Virgili, Department of electronic Engineering & IISPV
- Maria Vinaixa
- Universitat Rovira i Virgili, Department of electronic Engineering & IISPV
- Daniel López-López
- Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, c/Manuel Siurot s/n
- José Carlos Reyes
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Joaquín Dopazo
- Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, c/Manuel Siurot s/n
- Franz Martín
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Benoit R. Gauthier
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Morten Scheibye-Knudsen
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen
- Vivian Capilla-González
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- Alejandro Martín-Montalvo
- Andalusian Molecular Biology and Regenerative Medicine Centre-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide
- DOI
- https://doi.org/10.1038/s42003-023-04625-4
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 19
Abstract
A multiomic approach shows that long-term exposure to the Acly inhibitor SB-204990 modulates molecular mechanisms associated with aging.
