Nature Communications (Jul 2020)
PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis
- Slim Mzoughi,
- Jia Yi Fong,
- David Papadopoli,
- Cheryl M. Koh,
- Laura Hulea,
- Paolo Pigini,
- Federico Di Tullio,
- Giuseppe Andreacchio,
- Michal Marek Hoppe,
- Heike Wollmann,
- Diana Low,
- Matias J. Caldez,
- Yanfen Peng,
- Denis Torre,
- Julia N. Zhao,
- Oro Uchenunu,
- Gabriele Varano,
- Corina-Mihaela Motofeanu,
- Manikandan Lakshmanan,
- Shun Xie Teo,
- Cheng Mun Wun,
- Giovanni Perini,
- Soo Yong Tan,
- Chee Bing Ong,
- Muthafar Al-Haddawi,
- Ravisankar Rajarethinam,
- Susan Swee-Shan Hue,
- Soon Thye Lim,
- Choon Kiat Ong,
- Dachuan Huang,
- Siok-Bian Ng,
- Emily Bernstein,
- Dan Hasson,
- Keng Boon Wee,
- Philipp Kaldis,
- Anand Jeyasekharan,
- David Dominguez-sola,
- Ivan Topisirovic,
- Ernesto Guccione
Affiliations
- Slim Mzoughi
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Jia Yi Fong
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- David Papadopoli
- Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
- Cheryl M. Koh
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Laura Hulea
- Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
- Paolo Pigini
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Federico Di Tullio
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Giuseppe Andreacchio
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Michal Marek Hoppe
- Cancer Science Institute (CSI), National University of Singapore
- Heike Wollmann
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Diana Low
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Matias J. Caldez
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Yanfen Peng
- Cancer Science Institute (CSI), National University of Singapore
- Denis Torre
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Julia N. Zhao
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Oro Uchenunu
- Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
- Gabriele Varano
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Corina-Mihaela Motofeanu
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Manikandan Lakshmanan
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Shun Xie Teo
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Cheng Mun Wun
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Giovanni Perini
- Department of Pharmacy and Biotechnology, University of Bologna
- Soo Yong Tan
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Chee Bing Ong
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Muthafar Al-Haddawi
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Ravisankar Rajarethinam
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Susan Swee-Shan Hue
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Soon Thye Lim
- Division of Medical Oncology, National Cancer Centre Singapore
- Choon Kiat Ong
- Duke-NUS Graduate Medical School
- Dachuan Huang
- Division of Cellular and Molecular Research, National Cancer Centre Singapore
- Siok-Bian Ng
- Cancer Science Institute (CSI), National University of Singapore
- Emily Bernstein
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Dan Hasson
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Keng Boon Wee
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Philipp Kaldis
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Anand Jeyasekharan
- Cancer Science Institute (CSI), National University of Singapore
- David Dominguez-sola
- Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Ivan Topisirovic
- Lady Davis Institute, SMBD JGH, McGill University, Gerald Bronfman Department of Oncology, McGill University
- Ernesto Guccione
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-020-17064-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.
