Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

Eleanor Sinclair; Drupad K. Trivedi; Depanjan Sarkar; Caitlin Walton-Doyle; Joy Milne; Tilo Kunath; Anouk M. Rijs; Rob M. A. de Bie; Royston Goodacre; Monty Silverdale; Perdita Barran

doi:10.1038/s41467-021-21669-4

Nature Communications (Mar 2021)

Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

Eleanor Sinclair,
Drupad K. Trivedi,
Depanjan Sarkar,
Caitlin Walton-Doyle,
Joy Milne,
Tilo Kunath,
Anouk M. Rijs,
Rob M. A. de Bie,
Royston Goodacre,
Monty Silverdale,
Perdita Barran

Affiliations

Eleanor Sinclair: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester
Drupad K. Trivedi: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester
Depanjan Sarkar: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester
Caitlin Walton-Doyle: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester
Joy Milne: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester
Tilo Kunath: Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh
Anouk M. Rijs: Division of BioAnalytical Chemistry, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam
Rob M. A. de Bie: Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Centers, University of Amsterdam
Royston Goodacre: Institute of Systems, Molecular and Integrative Biology, Department of Biochemistry and Systems Biology, University of Liverpool
Monty Silverdale: Department of Neurology, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, University of Manchester
Perdita Barran: Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester

DOI: https://doi.org/10.1038/s41467-021-21669-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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Studies of metabolites in neurodegeneration have not yet used sebum as a source fluid. Here the authors demonstrate the potential of metabolomics of sebum samples from individuals with Parkinson’s disease and controls.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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