To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes

• Kyle I. P. Le Huray,
• Tobias P. Wörner,
• Tiago Moreira,
• Marcin Dembek,
• Maria Reinhardt-Szyba,
• Paul W. A. Devine,
• Nicholas J. Bond,
• Kyle L. Fort,
• Alexander A. Makarov,
• Frank Sobott

Affiliations

Kyle I. P. Le Huray

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.

Tobias P. Wörner

Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany

Tiago Moreira

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.

Marcin Dembek

Purification Process Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Cambridge, U.K.

Maria Reinhardt-Szyba

Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany

Paul W. A. Devine

Analytical Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Cambridge, U.K.

Nicholas J. Bond

Analytical Sciences, Biopharmaceutical Development, Biopharmaceuticals R&D, AstraZeneca, Cambridge, U.K.

Kyle L. Fort

Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany

Alexander A. Makarov

Thermo Fisher Scientific (Bremen) GmbH, Bremen, Germany

Frank Sobott

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, U.K.