Frontiers in Molecular Biosciences (Jul 2021)
The Biogenesis, Biological Functions, and Applications of Macrophage-Derived Exosomes
- Xiaoxiao Shan,
- Xiaoxiao Shan,
- Xiaoxiao Shan,
- Caiyun Zhang,
- Caiyun Zhang,
- Caiyun Zhang,
- Chutian Mai,
- Xuerui Hu,
- Xuerui Hu,
- Xuerui Hu,
- Nuo Cheng,
- Nuo Cheng,
- Nuo Cheng,
- Weidong Chen,
- Weidong Chen,
- Weidong Chen,
- Daiyin Peng,
- Daiyin Peng,
- Lei Wang,
- Lei Wang,
- Lei Wang,
- Zhaojie Ji,
- Zhaojie Ji,
- Ying Xie
Affiliations
- Xiaoxiao Shan
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Xiaoxiao Shan
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Xiaoxiao Shan
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Caiyun Zhang
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Caiyun Zhang
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Caiyun Zhang
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Chutian Mai
- State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, China
- Xuerui Hu
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Xuerui Hu
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Xuerui Hu
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Nuo Cheng
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Nuo Cheng
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Nuo Cheng
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Weidong Chen
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Weidong Chen
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Weidong Chen
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Daiyin Peng
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Daiyin Peng
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Lei Wang
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Lei Wang
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Lei Wang
- Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Hefei, China
- Zhaojie Ji
- School of Pharmacy, Anhui Academy of Chinese Medicine, , Anhui University of Traditional Chinese MedicineHefei, China
- Zhaojie Ji
- Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, China
- Ying Xie
- State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, China
- DOI
- https://doi.org/10.3389/fmolb.2021.715461
- Journal volume & issue
-
Vol. 8
Abstract
Macrophage-derived exosomes have been implicated on the modulation of inflammatory processes. Recent studies have shown that macrophage-derived exosomes contribute to the progression of many diseases such as cancer, atherosclerosis, diabetes and heart failure. This review describes the biogenesis of macrophage-derived exosomes and their biological functions in different diseases. In addition, the challenges facing the use of macrophage-derived exosomes as delivery tools for drugs, genes, and proteins in clinical applications are described. The application of macrophage-derived exosomes in the diagnosis and treatment of diseases is also discussed.
Keywords
