Research progress of single⁃cell omics in central nervous system immune diseases

Abstract

Central nervous system immune diseases include multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), myelin oligodendrocyte glycoprotein⁃IgG associated disorders (MOGAD) and anti⁃N⁃methyl⁃D⁃aspartate receptor (NMDAR) encephalitis. The pathogenesis of these diseases is complex, and a variety of central nervous system and peripheral cells are involved. Single⁃cell omics has achieved high⁃resolution detection of the expression profile at the level of single⁃cell through a series of sequencing techniques to analyze cell heterogeneity and functional phenotype. This review will summarize the single cell sequencing (SCS) and its applications in the above⁃mentioned diseases.

Keywords

• autoimmune diseases
• central nervous system diseases
• sequence analysis
• b ⁃ lymphocytes
• t⁃lymphocytes
• monocytes
• macrophages
• microglia
• dendritic cells
• review