Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation

Huiping Liao; Yuchao Zhang; Wei Guo; Xi Wang; Hailong Wang; Haocheng Ye; Kai Wu; Yu-Hang Zhang; Lingyun Guo; Yufei Zhu; Yongli Guo; Landian Hu; Gang Liu; Xiangyin Kong

doi:10.1128/mSystems.00049-21

mSystems (Jun 2021)

Characterization of the Blood and Cerebrospinal Fluid Microbiome in Children with Bacterial Meningitis and Its Potential Correlation with Inflammation

Huiping Liao,
Yuchao Zhang,
Wei Guo,
Xi Wang,
Hailong Wang,
Haocheng Ye,
Kai Wu,
Yu-Hang Zhang,
Lingyun Guo,
Yufei Zhu,
Yongli Guo,
Landian Hu,
Gang Liu,
Xiangyin Kong

Affiliations

Huiping Liao: ORCiD; Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Yuchao Zhang: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Wei Guo: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Xi Wang: Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
Hailong Wang: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Haocheng Ye: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Kai Wu: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Yu-Hang Zhang: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Lingyun Guo: Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
Yufei Zhu: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Yongli Guo: Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
Landian Hu: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China
Gang Liu: Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China
Xiangyin Kong: Key Laboratory of Molecular Genetics, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, China

DOI: https://doi.org/10.1128/mSystems.00049-21
Journal volume & issue: Vol. 6, no. 3

Abstract

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This study revealed the microbial compositions in children with bacterial meningitis who were treated with antibiotics and made a comprehensive comparison between blood and CSF specimens for risk and prognosis assessment. We found that microbiome signatures could distinguish patient subsets and were correlated with the CRP level in blood and granulocyte percentage in CSF.

Published in mSystems

ISSN: 2379-5077 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msystems

About the journal