Evaluation of Preoperative Tamsulosin Role in Facilitating Ureteral Orifice Navigation for School-Age Pediatric Ureteroscopy

Abstract

Chad Morley,1 Ali Hajiran,1 Amr A Elbakry,1 Hosam S AL-Qudah,2 Osama AL-Omar1 1Department of Urology, West Virginia University, Morgantown, WV, USA; 2Division of Urology, AL Zahra Hospital, Dubai, United Arab EmiratesCorrespondence: Osama AL-OmarDepartment of Urology, West Virginia University, PO Box 9238, 6300 HSS, Morgantown, WV, PO Box 9238, 6300 HSS, USATel [phone]Fax [phone]Email [email protected]: To address whether preoperative tamsulosin increases the rate of successful ureteral orifice navigation for ureteroscopy (URS) without prestenting in school-age pediatric patients.Methods: We retrospectively reviewed all pediatric patients who had undergone ureteroscopy (URS) at our institution from 2013 to 2020. Patients were divided into two groups: those who had received tamsulosin 0.4 mg daily ≥ 48 hours preoperatively and those who had not. Statistical analysis was done using independent-sample t-tests and Mann–Whitney U tests for continuous variables, and χ2 and Fisher’s exact tests were used for categorical variables. Multivariate analysis was done using binary logistic regression test.Results: Overall, successful ureteral orifice navigation occurred in 44 of 50 patients (88%) who had received tamsulosin and 17 of 26 (65.4%) who had not (p=0.019). On further subanalysis based on stone location and instrumentation used, successful ureteral orifice navigation had occurred in 21 of 24 patients (87.5%) in the tamsulosin group and one of five (20%) in the no-tamsulosin group for semirigid ureteroscopy for mid–distal ureterolithiasis (p=0.007). For proximal ureteral and renal stones, successful ureteral orifice navigation with a flexible ureteroscope or ureteral access sheath had occurred in 23 of 26 patients (88.5%) in the tamsulosin group and 16 of 21 (76.2%) in the no-tamsulosin group (p=0.437). Multivariate analysis showed no significant difference between success rates in the two groups after controlling for patient weight, height, BMI, and stone location. We did not observe any adverse effects from tamsulosin.Conclusion: This is the first study to evaluate preoperative tamsulosin on successful ureteral orifice navigation in school-age pediatric patients. Although not reaching statistical significance, further evaluation should be done on larger cohorts. Patient height was found to be an independent predictor of successful ureteral orifice navigation.Keywords: ureteroscopy, pediatric, tamsulosin, ureteral orifice navigation, α-blockers, renal stone

Keywords

• ureteroscopy
• pediatric
• tamsulosin
• ureteral orifice navigation
• alpha blockers
• renal stone.