Extracorporeal Photopheresis Reduces Fibrotic and Inflammatory Transcriptomic Biological Marker of Chronic Antibody-mediated Kidney Rejection

Arnaud Lionet, MD; Marine Van Triempon, MD; Martin Figeac, MD, PhD; Victor Fages, MD; Jean-Baptiste Gibier, MD, PhD; François Provot, MD; Mehdi Maanaoui, MD; Nicolas Pottier, PharmD, PhD; Christelle Cauffiez, PhD; François Glowacki, MD, PhD

doi:10.1097/TXD.0000000000001587

Transplantation Direct (Mar 2024)

Extracorporeal Photopheresis Reduces Fibrotic and Inflammatory Transcriptomic Biological Marker of Chronic Antibody-mediated Kidney Rejection

Arnaud Lionet, MD,
Marine Van Triempon, MD,
Martin Figeac, MD, PhD,
Victor Fages, MD,
Jean-Baptiste Gibier, MD, PhD,
François Provot, MD,
Mehdi Maanaoui, MD,
Nicolas Pottier, PharmD, PhD,
Christelle Cauffiez, PhD,
François Glowacki, MD, PhD

Affiliations

Arnaud Lionet, MD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Marine Van Triempon, MD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Martin Figeac, MD, PhD: 3 CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41—UAR 2014—PLBS, University of Lille, Lille, France.
Victor Fages, MD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Jean-Baptiste Gibier, MD, PhD: 4 Pathology Departement, CHU-Lille, France.
François Provot, MD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Mehdi Maanaoui, MD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.
Nicolas Pottier, PharmD, PhD: 2 CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277—CANTHER, University of Lille, Lille, France.
Christelle Cauffiez, PhD: 2 CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277—CANTHER, University of Lille, Lille, France.
François Glowacki, MD, PhD: 1 Department of Nephrology and Kidney Transplantation, University Hospital Huriez, CHU-Lille, Lille, France.

DOI: https://doi.org/10.1097/TXD.0000000000001587
Journal volume & issue: Vol. 10, no. 3
p. e1587

Abstract

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Background. The benefit of extracorporeal photopheresis on the course of kidney transplant rejection is unknown. The aim of our study was to investigate the variations in transcriptomics on graft biopsies when extracorporeal photopheresis was used to treat chronic humoral rejection after kidney transplantation. Methods. We retrospectively analyzed the mRNA expression of 770 genes of interest in graft biopsies performed before and after treatment. Eight patients received an average of 23 extracorporeal photopheresis sessions over 4 mo between the 2 biopsies. Results. Transcriptomic analysis of the graft biopsies identified a significant (adjusted P < 0.05) increase in CAV1 mRNA in all patients and a significant decrease in CD19, IL21, PAX5, and SFTPA2 mRNAs in 7 of 8 patients. Conclusions. In patients treated with extracorporeal photopheresis for chronic humoral rejection after renal transplantation, omic analysis of repeated biopsies shows a reduction in fibrotic and inflammatory transcriptomic biologicals markers.

Published in Transplantation Direct

ISSN: 2373-8731 (Online)
Publisher: Wolters Kluwer
Country of publisher: United States
LCC subjects: Medicine: Surgery
Website: http://journals.lww.com/transplantationdirect/Pages/default.aspx

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