NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Christine L. Zimmer; Martin Cornillet; Carles Solà-Riera; Ka-Wai Cheung; Martin A. Ivarsson; Mei Qiu Lim; Nicole Marquardt; Yee-Sin Leo; David Chien Lye; Jonas Klingström; Paul A. MacAry; Hans-Gustaf Ljunggren; Laura Rivino; Niklas K. Björkström

doi:10.1038/s41467-019-11878-3

Nature Communications (Aug 2019)

NK cells are activated and primed for skin-homing during acute dengue virus infection in humans

Christine L. Zimmer,
Martin Cornillet,
Carles Solà-Riera,
Ka-Wai Cheung,
Martin A. Ivarsson,
Mei Qiu Lim,
Nicole Marquardt,
Yee-Sin Leo,
David Chien Lye,
Jonas Klingström,
Paul A. MacAry,
Hans-Gustaf Ljunggren,
Laura Rivino,
Niklas K. Björkström

Affiliations

Christine L. Zimmer: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Martin Cornillet: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Carles Solà-Riera: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Ka-Wai Cheung: Programme in Emerging Infectious Diseases, DUKE-NUS Medical School
Martin A. Ivarsson: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Mei Qiu Lim: Programme in Emerging Infectious Diseases, DUKE-NUS Medical School
Nicole Marquardt: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Yee-Sin Leo: Institute of Infectious Diseases and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital
David Chien Lye: Institute of Infectious Diseases and Epidemiology, Communicable Disease Centre, Tan Tock Seng Hospital
Jonas Klingström: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Paul A. MacAry: Immunology Programme, Life Science Institute and Department of Microbiology and Immunology, National University of Singapore
Hans-Gustaf Ljunggren: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital
Laura Rivino: Programme in Emerging Infectious Diseases, DUKE-NUS Medical School
Niklas K. Björkström: Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital

DOI: https://doi.org/10.1038/s41467-019-11878-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Here, Zimmer et al. analyze the natural killer (NK) cell response in a patient cohort with acute dengue virus infection showing early NK cell activation and proliferation, and the data suggest that NK cell proliferation depends on IL-18 signaling, and that responding NK cells have a skin-homing phenotype.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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