Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO

O. Hunsicker; L. Materne; V. Bünger; A. Krannich; F. Balzer; C. Spies; R. C. Francis; S. Weber-Carstens; M. Menk; J. A. Graw

doi:10.1186/s13054-020-03405-4

Critical Care (Dec 2020)

Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO

O. Hunsicker,
L. Materne,
V. Bünger,
A. Krannich,
F. Balzer,
C. Spies,
R. C. Francis,
S. Weber-Carstens,
M. Menk,
J. A. Graw

Affiliations

O. Hunsicker: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
L. Materne: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
V. Bünger: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
A. Krannich: Clinical Trial Office, Charité - Universitätsmedizin Berlin
F. Balzer: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
C. Spies: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
R. C. Francis: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
S. Weber-Carstens: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
M. Menk: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
J. A. Graw: Department of Anesthesiology and Operative Intensive Care Medicine CCM / CVK Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health

DOI: https://doi.org/10.1186/s13054-020-03405-4
Journal volume & issue: Vol. 24, no. 1
pp. 1 – 12

Abstract

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Abstract Background Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of two transfusion thresholds on short-term outcome in patients with ARDS. Methods Patients who received transfusions of RBCs were identified from a cohort of 1044 ARDS patients. After propensity score matching, patients transfused at a hemoglobin concentration of 8 g/dl or less (lower-threshold) were compared to patients transfused at a hemoglobin concentration of 10 g/dl or less (higher-threshold). The primary endpoint was 28-day mortality. Secondary endpoints included ECMO-free, ventilator-free, sedation-free, and organ dysfunction-free composites. Measurements and main results One hundred ninety-two patients were eligible for analysis of the matched cohort. Patients in the lower-threshold group had similar baseline characteristics and hemoglobin levels at ARDS onset but received fewer RBC units and had lower hemoglobin levels compared with the higher-threshold group during the course on the ICU (9.1 [IQR, 8.7–9.7] vs. 10.4 [10–11] g/dl, P < 0.001). There was no difference in 28-day mortality between the lower-threshold group compared with the higher-threshold group (hazard ratio, 0.94 [95%-CI, 0.59–1.48], P = 0.78). Within 28 days, 36.5% (95%-CI, 27.0–46.9) of the patients in the lower-threshold group compared with 39.5% (29.9–50.1) of the patients in the higher-threshold group had died. While there were no differences in ECMO-free, sedation-free, and organ dysfunction-free composites, the chance for successful weaning from mechanical ventilation within 28 days after ARDS onset was lower in the lower-threshold group (subdistribution hazard ratio, 0.36 [95%-CI, 0.15–0.86], P = 0.02). Conclusions Transfusion at a hemoglobin concentration of 8 g/dl, as compared with a hemoglobin concentration of 10 g/dl, was not associated with an increase in 28-day mortality in adults with ARDS. However, a transfusion at a hemoglobin concentration of 8 g/dl was associated with a lower chance for successful weaning from the ventilator during the first 28 days after ARDS onset. Trial Registration: ClinicalTrials.gov NCT03871166.

Published in Critical Care

ISSN: 1364-8535 (Print); 1466-609X (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Medical emergencies. Critical care. Intensive care. First aid
Website: https://ccforum.biomedcentral.com/

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